{"created":"2023-07-25T08:14:56.539998+00:00","id":16138,"links":{},"metadata":{"_buckets":{"deposit":"ffc007a0-e053-40d8-bdc9-e33762d3e1b6"},"_deposit":{"created_by":18,"id":"16138","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16138"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016138","sets":["57:86"]},"author_link":["140760"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-06-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-06-13"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"OBJECTIVES: The present study investigated whether or not pleural anthracosis is associated with changes in the pleural lymphatic structures or function, which would interfere with nodal skip metastasis.\nMETHODS: This study comprised 2 different case series. In the first series, we observed pleural lymphatic drainage using near-infrared fluorescent endoscopy by the subpleural injection of indocyanine green immediately after thoracotomy for lung cancer. We also performed a histological assessment of the pleura. In the second series, we reviewed the nodal metastatic pattern (skip or non-skip metastasis) in pathological N2 lung cancer involving the pleura. These findings were compared with the severity of pleural anthracosis, which was quantified by thoracoscopic vision and a software-based imaging analysis.\nRESULTS: In the first series (n = 42), pleural lymphatic drainage was not visualized in 19 (45%) patients who had relatively severe anthracosis, while it was visualized in the remaining 23 (55%) patients who had relatively minimal anthracosis. Histologically, severe anthracosis was associated with pleural thickening accompanied by a decreased incidence of straight-running lymphatic vessels and, in turn, an increased incidence of short lymphatic vessels, which was suggested to be the result of pleural remodelling. In the second series (n = 53), a skip metastatic pattern was found in 24 (45%) patients who predominantly had less-severe anthracosis, while a non-skip metastatic pattern was found in 29 (55%) patients who predominantly had severe anthracosis.\nCONCLUSIONS: Pleural anthracosis was associated with pathological changes in the pleural lymphatics and decreased pleural lymphatic drainage, thereby interfering with nodal skip metastasis.\n\nThis is a pre-copyedited, author-produced version of an article accepted for publication in [European Journal of Cardio-Thoracic Surgery] following peer review. The version of record [Aya Takeda, Kazuhiro Ueda, Masaya Aoki, Toshiyuki Nagata, Go Kamimura, Tadashi Umehara, Takuya Tokunaga, Kazuhiro Tabata, Akihide Tanimoto, Masami Sato, \"Altered lymphatic structure and function in pleural anthracosis: negative role in skip N2 metastasis\"; European Journal of Cardio-Thoracic Surgery 2022, 62(3), ezac123] is available online at: https://academic.oup.com/ejcts/article/62/3/ezac123/6535926 [https://doi.org/10.1093/ejcts/ezac123].","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第663号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:佐藤雅美】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-04-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武田, 亜矢","creatorNameLang":"ja"},{"creatorName":"タケダ, アヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeda, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-06-13"}],"displaytype":"detail","filename":"Diss_武田_亜矢_ISK663_2022.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_武田_亜矢_ISK663_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16138/files/Diss_武田_亜矢_ISK663_2022.pdf"},"version_id":"f688d406-5996-48f9-8b48-98e49324698f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-21"}],"displaytype":"detail","filename":"Abstract_武田_亜矢_4519810221_2022.pdf","filesize":[{"value":"24.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_武田_亜矢_4519810221_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16138/files/Abstract_武田_亜矢_4519810221_2022.pdf"},"version_id":"2d8b473e-e616-4573-99ad-22a62a9a02ea"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-21"}],"displaytype":"detail","filename":"Result_Takeda_Aya_isk_663.pdf","filesize":[{"value":"120.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_Takeda_Aya_isk_663","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16138/files/Result_Takeda_Aya_isk_663.pdf"},"version_id":"4ae2a553-b361-46ca-bd4a-b6be6002fc8a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-06-21"}],"displaytype":"detail","filename":"Comments_Takeda_Aya_isk_663.pdf","filesize":[{"value":"56.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_Takeda_Aya_isk_663","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16138/files/Comments_Takeda_Aya_isk_663.pdf"},"version_id":"dee9120b-43fb-4ff6-b95f-8a03b09479b9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pleural lymphatics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Indocyanine green fluorescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anthracosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Skip lymph node metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Altered lymphatic structure and function in pleural anthracosis: Negative role in skip N2 metastasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Altered lymphatic structure and function in pleural anthracosis: Negative role in skip N2 metastasis","subitem_title_language":"en"},{"subitem_title":"炭粉沈着をきたした胸膜におけるリンパ管の構造的・機能的変化: リンパ節スキップ転移への影響","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-21"},"publish_date":"2022-06-21","publish_status":"0","recid":"16138","relation_version_is_last":true,"title":["Altered lymphatic structure and function in pleural anthracosis: Negative role in skip N2 metastasis"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:07:37.747222+00:00"}