{"created":"2023-07-25T08:15:01.058909+00:00","id":16232,"links":{},"metadata":{"_buckets":{"deposit":"b9526d71-1b7b-4065-ad9a-fb19e33e6765"},"_deposit":{"created_by":18,"id":"16232","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16232"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016232","sets":["57:86"]},"author_link":["141287"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-09-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-09-13"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. Results: SOX9 was expressed (moderately or strongly) in 62.9% of samples. Expression of SOX9 was significantly positively correlated with depth of invasion, advanced stage, lymphatic and venous invasion, and poor prognosis. Univariate analysis showed that depth of invasion, lymph node metastasis, distant metastasis, stage, lymphatic invasion, venous invasion, and SOX9 expression were prognostic factors. Multivariate analysis indicated that depth of invasion and stage were independent prognostic factors, but SOX9 expression was not. Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor.\nOesophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract (1). There have been many studies of the effects of various biological factors on the malignant potential of ESCC. Sex-determining region Y-box 9 (SOX9) is an important transcriptional factor for the development and differentiation of cells and their organization (2). Recently, there have been reports of a correlation between SOX9 expression and clinical outcomes in some cancer types, including gastrointestinal tract cancer (3-9). The aims of this retrospective study were to examine the expression of SOX9 protein in surgical specimens from patients with ESCC treated with radical surgery and to evaluate whether such expression is useful for predicting their outcome.\n\nNAOTOMO HIGO, HIROSHI OKUMURA, YASUTO UCHIKADO, ITARU OMOTO, KEN SASAKI, YOSHIAKI KITA, DESAKI RYOSUKE, MASAHIRO NODA, TETSUHIRO OWAKI, SUMIYA ISHIGAMI and SHOJI NATSUGOE\nExpression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma\nIn Vivo 32: 835-838 (2018)\nhttps://doi.org/10.21873/invivo.11316","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第668号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大塚隆生】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2021-09-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"肥後, 直倫","creatorNameLang":"ja"},{"creatorName":"ヒゴ, ナオトモ","creatorNameLang":"ja-Kana"},{"creatorName":"Higo, Naotomo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"141287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-04"}],"displaytype":"detail","filename":"Diss_肥後_直倫_ISK668_2022.pdf","filesize":[{"value":"195.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_肥後_直倫_ISK668_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16232/files/Diss_肥後_直倫_ISK668_2022.pdf"},"version_id":"55d072f5-f9dc-4592-9d79-a2f14924d812"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-20"}],"displaytype":"detail","filename":"Abstract_肥後_直倫_4512810345_2022.pdf","filesize":[{"value":"33.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_肥後_直倫_4512810345_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16232/files/Abstract_肥後_直倫_4512810345_2022.pdf"},"version_id":"3e23e3d1-2f83-4454-8f8d-3776b6f1fe01"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-19"}],"displaytype":"detail","filename":"Result_higo_Naotomo_isk_668.pdf","filesize":[{"value":"140.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_higo_Naotomo_isk_668","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16232/files/Result_higo_Naotomo_isk_668.pdf"},"version_id":"5cc63dd7-c99d-4943-9868-f226cc4fc40d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-19"}],"displaytype":"detail","filename":"Comments_higo_Naotomo_isk_668.pdf","filesize":[{"value":"74.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_higo_Naotomo_isk_668","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16232/files/Comments_higo_Naotomo_isk_668.pdf"},"version_id":"60ddfc37-c3b5-4887-ab4a-dc4d835a0412"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SOX9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oesophageal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma","subitem_title_language":"en"},{"subitem_title":"食道扁平上皮癌患者においてSOX9の発現は予後に関連している","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-09-20"},"publish_date":"2022-09-20","publish_status":"0","recid":"16232","relation_version_is_last":true,"title":["Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:07:52.104143+00:00"}