{"created":"2023-07-25T08:15:01.105375+00:00","id":16233,"links":{},"metadata":{"_buckets":{"deposit":"f6c16349-7df7-4e86-a4a8-c3a15fa501cf"},"_deposit":{"created_by":18,"id":"16233","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16233"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016233","sets":["57:86"]},"author_link":["141290"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-09-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2022-09-13"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are at greater risk of dementia than those with MCI or PF alone, but there are few known clinical or neuroimaging features to reliably distinguish CF from PF or MCI. We therefore conducted a population-based cross-sectional study of community elderly combining physical, cognitive, neuropsychiatric, and multisequence magnetic resonance imaging (MRI) evaluations. The MRI evaluation parameters included white matter (WM) lesion volumes, perivascular and deep subcortical WM lesion grades, lacunar infarct prevalence, microbleed number, and regional medial temporal lobe (MTL) volumes. Participants were divided into 4 groups according to the presence or absence of MCI and PF—(1) no MCI, PF (n = 27); (2) no PF, MCI (n = 119); (3) CF (MCI + PF) (n = 21), (4) normal controls (n = 716). Unique features of CF included shorter one-leg standing time; severe depressive symptoms; and MRI signs of significantly more WM lesions, lacunar infarcts, small-vessel disease lesions, microbleeds, and reduced MTL volumes. These unique deficits suggest that interventions for CF prevention and treatment should focus on motor skills, depressive symptoms, and vascular disease risk factor control.\n\nKazuhiro Yoshiura, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Yusuke Miyagawa, Yosuke Hidaka, Mamoru Hashimoto, Manabu Ikeda, Minoru Takebayashi & Megumi Shimodozono\nBrain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD)\nScientific Reports 12, 8202 (2022)\nhttps://doi.org/10.1038/s41598-022-12195-4","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第669号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Research","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:下堂薗恵】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-07-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉浦, 和宏","creatorNameLang":"ja"},{"creatorName":"ヨシウラ, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshiura, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-01"}],"displaytype":"detail","filename":"Diss_吉浦_和宏_ISK669_2022.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_吉浦_和宏_ISK669_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16233/files/Diss_吉浦_和宏_ISK669_2022.pdf"},"version_id":"d5e542d6-031d-4679-9fcf-d27da0a09aec"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-20"}],"displaytype":"detail","filename":"Abstract_吉浦_和宏_4514810273_2022.pdf","filesize":[{"value":"76.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_吉浦_和宏_4514810273_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16233/files/Abstract_吉浦_和宏_4514810273_2022.pdf"},"version_id":"5d29e204-b06c-4996-9622-01be31cc50f0"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-19"}],"displaytype":"detail","filename":"Result_Yoshiura_Kazuhiro_isk_669.pdf","filesize":[{"value":"142.8 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(JPSC-AD)"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:07:53.968142+00:00"}