{"created":"2023-07-25T08:15:15.215474+00:00","id":16527,"links":{},"metadata":{"_buckets":{"deposit":"62a71f96-0aba-41d2-b2a2-61413a6839fe"},"_deposit":{"created_by":18,"id":"16527","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16527"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016527","sets":["57:86"]},"author_link":["142146"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-10"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Platelet functions are thought to contribute to clinical outcomes after heart surgery. This study was conducted to assess the pivotal roles of vascular endothelial growth factor-A (VEGF-A) and microRNA-126 (miR-126) during coronary artery bypass grafting (CABG). Whole blood was collected for platelet isolation from 67 patients who underwent CABG surgery between July 2013 and March 2014. VEGF-A and miR-126 levels in serum, plasma, and platelets were measured at various time points and compared with clinical characteristics. The platelet count was decreased at 3 days after CABG. This dynamic change in platelet count was larger after conventional coronary artery bypass (CCAB) than off-pump coronary artery bypass (OPCAB). VEGF-A in the same number of platelets (IP-VEGF-A) was increased at 3 days after CABG, followed by an increase of VEGF-A in serum (S-VEGF-A) at 7 days after surgery. The miR-126-3p level in serum (S-miR-126-3p) increased rapidly after CABG and then decreased below preoperative levels. The IP-VEGF-A level on day 7 after CABG in patients with peripheral artery disease (PAD), who suffered from endothelial dysfunction, was higher compared with patients without PAD. Conversely, S-miR-126-3p on day 7 after surgery was lower in patients with PAD than in patients without PAD. Low levels of S-miR-126-3p due to endothelial dysfunction may lead to high IP-VEGF-A, which is closely related to complications after CABG.\n\nKosuke Mukaihara, Munekazu Yamakuchi, Hideaki Kanda, Yoshiya Shigehisa, Kenichi Arata, Kazuhisa Matsumoto, Kazunori Takenouchi, Yoko Oyama, Toyoyasu Koriyama, Teruto Hashiguchi & Yutaka Imoto\nEvaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting\nHeart and Vessels 36, 1635–1645 (2021)\n\nThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00380-021-01855-6","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第683号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:曽我欣治】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-12-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"向原, 公介","creatorNameLang":"ja"},{"creatorName":"ムカイハラ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Mukaihara, Kosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142146","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-20"}],"displaytype":"detail","filename":"Diss_向原_公介_ISK683_2022.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_向原_公介_ISK683_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16527/files/Diss_向原_公介_ISK683_2022.pdf"},"version_id":"49035922-5af7-4b68-92c9-21e4d8f40eb7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-14"}],"displaytype":"detail","filename":"Abstract_向原_公介_4514810255_2022.pdf","filesize":[{"value":"127.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_向原_公介_4514810255_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16527/files/Abstract_向原_公介_4514810255_2022.pdf"},"version_id":"a4b357a1-f8e4-4648-838b-14ef19bd57c2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Result_MUKAIHARA_Kosuke_isk_683.pdf","filesize":[{"value":"111.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_MUKAIHARA_Kosuke_isk_683","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16527/files/Result_MUKAIHARA_Kosuke_isk_683.pdf"},"version_id":"2b6f08b1-1a2e-46a6-a6d2-6900f1b73b14"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Comments_MUKAIHARA_Kosuke_isk_683.pdf","filesize":[{"value":"61.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_MUKAIHARA_Kosuke_isk_683","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16527/files/Comments_MUKAIHARA_Kosuke_isk_683.pdf"},"version_id":"4bd4b780-7911-42d0-884d-e78e716f2707"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"VEGF-A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Platelet","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MicroRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MiR-126","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CABG","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting","subitem_title_language":"en"},{"subitem_title":"冠動脈バイパス術後における血小板中VEGF-Aと血清中microRNA-126の解析","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-14"},"publish_date":"2023-03-14","publish_status":"0","recid":"16527","relation_version_is_last":true,"title":["Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:12:23.788645+00:00"}