{"created":"2023-07-25T08:15:15.262161+00:00","id":16528,"links":{},"metadata":{"_buckets":{"deposit":"6903e66d-1cf2-4cef-b54b-4247f31acc90"},"_deposit":{"created_by":18,"id":"16528","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16528"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016528","sets":["57:86"]},"author_link":["142149"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-10"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Oxidation of BH4, a cofactor of nitric oxide synthase (NOS), produces reactive oxygen species (ROS) through uncoupling of NOS and affects vascular endothelial dysfunction. Ascorbic acid (AsA) inhibits the oxidation of BH4 and reduces ROS. However, the kinetic changes of BH4 in sepsis and its effect on the kinetic changes in AsA administration therapy, as well as the appropriate timing of AsA administration for AsA therapy to be effective, are unclear. Mice with sepsis, induced by cecal ligation and puncture (CLP), were examined for the effect of AsA administration (200 mg/kg) on vascular endothelial cell dysfunction at two administration timings: early group (AsA administered immediately after CLP) and late group (AsA administered 12 h after CLP). Survival rates were compared between the early and late administration groups, and vascular endothelial cell damage, indicated by the dihydrobiopterin/tetrahydrobiopterin ratio, serum syndecan-1, and endothelial nitric oxide synthase, as well as liver damage, were examined. The early group showed significantly improved survival compared to the non-treatment group (p < 0.05), while the late group showed no improved survival compared to the non-treatment group. Compared to the non-treated group, the early AsA group showed less oxidation of BH4 in sepsis. Syndecan1, a marker of vascular endothelial cell damage, was less elevated and organ damage was reduced in the early AsA-treated group. In septic mice, early AsA administration immediately after CLP may protect vascular endothelial cells by inhibiting BH4 oxidation, thereby reducing organ dysfunction and improving survival.\n\nYutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose and Yasuyuki Kakihana\nEarly ascorbic acid administration prevents vascular endothelial cell damage in septic mice\nFrontiers in Pharmacology 13:929448\nhttps://doi.org/10.3389/fphar.2022.929448","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第684号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:垣花泰之】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-12-07"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"政所, 祐太郎","creatorNameLang":"ja"},{"creatorName":"マドコロ, ユウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Madokoro, Yutaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142149","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-20"}],"displaytype":"detail","filename":"Diss_政所_祐太郎_ISK684_2022.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_政所_祐太郎_ISK684_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16528/files/Diss_政所_祐太郎_ISK684_2022.pdf"},"version_id":"ce97ffa7-fd02-42cb-a000-019a03672f9e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-14"}],"displaytype":"detail","filename":"Abstract_政所_祐太郎_4517810348_2022.pdf","filesize":[{"value":"132.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_政所_祐太郎_4517810348_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16528/files/Abstract_政所_祐太郎_4517810348_2022.pdf"},"version_id":"94b9046c-996f-410a-b35c-6229c2af32f1"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Result_MADOKORO_Yutaro_isk_684.pdf","filesize":[{"value":"166.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_MADOKORO_Yutaro_isk_684","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16528/files/Result_MADOKORO_Yutaro_isk_684.pdf"},"version_id":"3ff2d842-a78d-402d-88f0-dedc978c5866"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Comments_MADOKORO_Yutaro_isk_684.pdf","filesize":[{"value":"57.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_MADOKORO_Yutaro_isk_684","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16528/files/Comments_MADOKORO_Yutaro_isk_684.pdf"},"version_id":"df8035ad-36af-4624-816a-d528cba1116f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ascorbic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sepsis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tetrahydrobiopterin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"syndecan","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice","subitem_title_language":"en"},{"subitem_title":"敗血症マウスにおける早期アスコルビン酸投与による血管内皮細胞障害の抑制","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-14"},"publish_date":"2023-03-14","publish_status":"0","recid":"16528","relation_version_is_last":true,"title":["Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:12:28.350127+00:00"}