{"created":"2023-07-25T08:15:15.395303+00:00","id":16531,"links":{},"metadata":{"_buckets":{"deposit":"1be79a0f-4fbb-4b28-9aba-80117c17b4f7"},"_deposit":{"created_by":18,"id":"16531","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16531"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016531","sets":["57:86"]},"author_link":["142158"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-10"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"In recent years, cancer metabolism has attracted attention as a therapeutic target, and glutamine metabolism is considered one of the most important metabolic processes in cancer. Solute carrier family 1 member 5 (SLC1A5) is a sodium channel that functions as a glutamine transporter. In various cancer types, SLC1A5 gene expression is enhanced, and cancer cell growth is suppressed by inhibition of SLC1A5. However, the involvement of SLC1A5 in clear cell renal cell carcinoma (ccRCC) is unclear. Therefore, in this study, we evaluated the clinical importance of SLC1A5 in ccRCC using The Cancer Genome Atlas database. Our findings confirmed that SLC1A5 was a prognosis factor for poor survival in ccRCC. Furthermore, loss-of-function assays using small interfering RNAs or an SLC1A5 inhibitor (V9302) in human ccRCC cell lines (A498 and Caki1) showed that inhibition of SLC1A5 significantly suppressed tumor growth, invasion, and migration. Additionally, inhibition of SLC1A5 by V9302 in vivo significantly suppressed tumor growth, and the antitumor effects of SLC1A5 inhibition were related to cellular senescence. Our findings may improve our understanding of ccRCC and the development of new treatment strategies for ccRCC.\n\nIssei Kawakami, Hirofumi Yoshino, Wataru Fukumoto, Motoki Tamai, Shunsuke Okamura, Yoichi Osako, Takashi Sakaguchi, Satoru Inoguchi, Ryosuke Matsushita, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida\nTargeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma\nBiochemical and Biophysical Research Communications 611 (2022) 99-106\nhttps://doi.org/10.1016/j.bbrc.2022.04.068","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第687号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:榎田英樹】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-06-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川上, 一誠","creatorNameLang":"ja"},{"creatorName":"カワカミ, イッセイ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakami, Issei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142158","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-25"}],"displaytype":"detail","filename":"Diss_川上_一誠_ISK687_2022.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_川上_一誠_ISK687_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16531/files/Diss_川上_一誠_ISK687_2022.pdf"},"version_id":"4103caed-6aa2-495c-b4ed-08c88046ac92"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-14"}],"displaytype":"detail","filename":"Abstract_川上_一誠_4518810119_2022.pdf","filesize":[{"value":"141.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_川上_一誠_4518810119_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16531/files/Abstract_川上_一誠_4518810119_2022.pdf"},"version_id":"ff43b249-7cb5-47b7-9619-5bbcf15face5"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Result_KAWAKAMI_Issei_isk_687.pdf","filesize":[{"value":"118.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_KAWAKAMI_Issei_isk_687","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16531/files/Result_KAWAKAMI_Issei_isk_687.pdf"},"version_id":"deb40156-a98b-40da-80d5-f3efc0aa3762"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Comments_KAWAKAMI_Issei_isk_687.pdf","filesize":[{"value":"50.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_KAWAKAMI_Issei_isk_687","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16531/files/Comments_KAWAKAMI_Issei_isk_687.pdf"},"version_id":"97a2915b-bd9f-40df-aa19-baa63f3318d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glutamine transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Solute carrier family 1 member 5","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"V9302","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cellular senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma","subitem_title_language":"en"},{"subitem_title":"グルタミントランスポーターSLC1A5の標的化は淡明細胞型腎細胞癌において細胞老化を誘導する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-14"},"publish_date":"2023-03-14","publish_status":"0","recid":"16531","relation_version_is_last":true,"title":["Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:12:35.983371+00:00"}