{"created":"2023-07-25T08:15:15.573733+00:00","id":16535,"links":{},"metadata":{"_buckets":{"deposit":"74c6f30b-412d-46c1-8f83-afddd412f8d8"},"_deposit":{"created_by":18,"id":"16535","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16535"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016535","sets":["57:86"]},"author_link":["142170"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Stable coronary artery disease (CAD) patients with myocardial damage have a poor prognosis compared to those without myocardial damage. Recently, malnutrition has been reported to affect the prognosis of cardiovascular diseases. However, the effects of malnutrition on prognosis of CAD patients with myocardial damage remains uncertain. We investigated the effects of malnutrition on prognosis of CAD patients with myocardial damage who received percutaneous coronary intervention (PCI).\nMethods: Subjects comprised 241 stable CAD patients with myocardial damage due to myocardial ischemia or infraction. Patients underwent successful revascularization for the culprit lesion by PCI using second-generation drug-eluting stents and intravascular ultrasound. The geriatric nutritional risk index (GNRI), which is widely used as a simple method for screening nutritional status using body mass index and serum albumin, was used to assess nutritional status. Associations between major cardiovascular and cerebrovascular events (MACCE) and patient characteristics were assessed.\nResults: Mean GNRI was 100 ± 13, and there were 55 malnourished patients (23%; GNRI < 92) and 186 non-malnourished patients (77%). MACCE occurred within 3 years after PCI in 42 cases (17%), including 34 deaths (14%), and the malnourished group showed a higher rate of MACCE (38%) compared with the non-malnourished group (11%, p < 0.001). Univariate Cox proportional hazards analyses showed that MACCE was associated with age [hazard ratio (HR), 1.04; 95% confidence interval (CI), 1.04–1.07; p = 0.004], prior heart failure (HR 2.35; 95% CI 1.10–5.01; p = 0.027), high-sensitivity C-reactive protein (HR 1.08; 95% CI 1.03–1.11; p < 0.001), hemodialysis (HR 2.63; 95% CI 1.51–4.58; p < 0.001) and malnutrition (HR 3.69; 95% CI 2.11–6.42; p < 0.001). Multivariate Cox proportional hazards analysis revealed hemodialysis (HR 2.17; 95% CI 1.19–3.93; p = 0.011) and malnutrition (HR 2.30; 95% CI 1.13–4.67; p = 0.020) as significantly associated with MACCE. Furthermore, Cox proportional hazards models using malnutrition and hemodialysis revealed that patients with malnutrition and hemodialysis were at greater risk of MACCE after PCI than patients with neither malnutrition nor hemodialysis (HR 6.91; 95% CI 3.29–14.54; p < 0.001).\nConclusions: In CAD patients with myocardial damage, malnutrition (GNRI < 92) represents an independent risk factor for MACCE. Assessment of nutritional status may help stratify the risk of cardiovascular events and encourage improvements in nutritional status.\n\nRyo Arikawa, Daisuke Kanda, Yoshiyuki Ikeda, Akihiro Tokushige, Takeshi Sonoda, Kazuhiro Anzaki & Mitsuru Ohishi\nPrognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage\nBMC Cardiovascular Disorders (2021) 21:479\nhttps://doi.org/10.1186/s12872-021-02296-9","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第691号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"BMC","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大石充】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-10-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"有川, 亮","creatorNameLang":"ja"},{"creatorName":"アリカワ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Arikawa, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-22"}],"displaytype":"detail","filename":"Diss_有川_亮_ISK691_2022.pdf","filesize":[{"value":"954.1 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"Diss_有川_亮_ISK691_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16535/files/Diss_有川_亮_ISK691_2022.pdf"},"version_id":"6ff8da8e-1d16-42c1-bb41-ed2be2120f3d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-14"}],"displaytype":"detail","filename":"Abstract_有川_亮_4519810015_2022.pdf","filesize":[{"value":"133.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_有川_亮_4519810015_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16535/files/Abstract_有川_亮_4519810015_2022.pdf"},"version_id":"5335b54c-a17e-41ce-b849-e06033e9994d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Result_ARIKAWA_Ryo_isk_691.pdf","filesize":[{"value":"114.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_ARIKAWA_Ryo_isk_691","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16535/files/Result_ARIKAWA_Ryo_isk_691.pdf"},"version_id":"32ea6731-8675-4ab8-989b-6bd396396d24"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Comments_ARIKAWA_Ryo_isk_691.pdf","filesize":[{"value":"57.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_ARIKAWA_Ryo_isk_691","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16535/files/Comments_ARIKAWA_Ryo_isk_691.pdf"},"version_id":"c1995769-a75c-4f7c-84d2-c9b3aff2d643"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Malnutrition","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Coronary artery disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Myocardial damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Percutaneous coronary intervention","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hemodialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage","subitem_title_language":"en"},{"subitem_title":"低栄養が心筋障害を伴う冠動脈疾患患者の予後に与える影響","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-14"},"publish_date":"2023-03-14","publish_status":"0","recid":"16535","relation_version_is_last":true,"title":["Prognostic impact of malnutrition on cardiovascular events in coronary artery disease patients with myocardial damage"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:12:48.281159+00:00"}