{"created":"2023-07-25T08:15:15.661245+00:00","id":16537,"links":{},"metadata":{"_buckets":{"deposit":"eca70bda-4cd1-44d0-8370-a65d4f1210ae"},"_deposit":{"created_by":18,"id":"16537","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16537"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016537","sets":["57:86"]},"author_link":["142176"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-03","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Hypertension is a risk factor for atherosclerosis. Achieving the therapeutic target value of blood pressure (BP) prevents the onset of cardiovascular events; however, it is not clear how antihypertensive drug use and BP control status relate to arterial stiffness. The purpose of this study is to investigate the relationship between BP control status with or without antihypertensive drugs and arterial stiffness. Nine hundred eighty individuals (mean age: 68 ± 11 years) who participated in a community-based cohort study were enrolled. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI). Higher BP was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg. Participants were divided into four groups: normal, non higher BP without antihypertensive drugs (n = 421); untreated, higher BP without antihypertensive drugs (n = 174); good control, non higher BP with antihypertensive drugs (n = 209); and poor control, higher BP with antihypertensive drugs (n = 176). In multivariable logistic analysis adjusted for age, sex, dyslipidemia and diabetes mellitus medication use, obesity, smoking, alcohol drinking, and heart rate at the CAVI measurement for a high CAVI—using a borderline cutoff value of 8.0—the other three groups were significantly associated with a high CAVI when compared with the normal group. By contrast, multivariable logistic analysis of a high CAVI using an abnormal cutoff value of 9.0 demonstrated that the poor control and untreated groups were significantly associated with a high CAVI, whereas the good control group was not. In conclusion, even with antihypertensive drugs, poor BP control is independently associated with a high CAVI.\n\nTakeko Kawabata, Takuro Kubozono, Satoko Ojima, Shin Kawasoe, Yuichi Akasaki, Anwar Ahmed Salim, Yoshiyuki Ikeda, Masaaki Miyata, Toshihiro Takenaka & Mitsuru Ohishi\nInsufficient blood pressure control is independently associated with increased arterial stiffness\nHypertension Research 45, 1861–1868 (2022)\nhttps://doi.org/10.1038/s41440-022-01039-3","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第693号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員:大石充】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-10-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川畑, 孟子","creatorNameLang":"ja"},{"creatorName":"カワバタ, タケコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawabata, Takeko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-20"}],"displaytype":"detail","filename":"Diss_川畑_孟子_ISK693_2022.pdf","filesize":[{"value":"457.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Diss_川畑_孟子_ISK693_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16537/files/Diss_川畑_孟子_ISK693_2022.pdf"},"version_id":"f240f01e-9286-48d9-b62d-7ebb40be0643"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-14"}],"displaytype":"detail","filename":"Abstract_川畑_孟子_4519810169_2022.pdf","filesize":[{"value":"83.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_川畑_孟子_4519810169_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16537/files/Abstract_川畑_孟子_4519810169_2022.pdf"},"version_id":"d618a1eb-080a-4410-9b71-3b81d29e720c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Result_KAWABATA_takeko_isk_693.pdf","filesize":[{"value":"113.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_KAWABATA_takeko_isk_693","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16537/files/Result_KAWABATA_takeko_isk_693.pdf"},"version_id":"d909e4a3-d322-445c-b77d-2964b966d15f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-19"}],"displaytype":"detail","filename":"Comments_KAWABATA_takeko_isk_693.pdf","filesize":[{"value":"56.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_KAWABATA_takeko_isk_693","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16537/files/Comments_KAWABATA_takeko_isk_693.pdf"},"version_id":"cbf64b60-a3c9-45c6-a3ae-e23b6f02d6ea"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antihypertensive agents","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Risk factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vascular stiffness","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Insufficient blood pressure control is independently associated with increased arterial stiffness","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Insufficient blood pressure control is independently associated with increased arterial stiffness","subitem_title_language":"en"},{"subitem_title":"不十分な血圧コントロールは独立して動脈硬化度の進行と関連する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-14"},"publish_date":"2023-03-14","publish_status":"0","recid":"16537","relation_version_is_last":true,"title":["Insufficient blood pressure control is independently associated with increased arterial stiffness"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-09T02:12:55.396379+00:00"}