{"created":"2023-07-25T08:15:16.456240+00:00","id":16555,"links":{},"metadata":{"_buckets":{"deposit":"fa9f3e3c-4abf-42b6-a936-f0fbccadeca9"},"_deposit":{"created_by":18,"id":"16555","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16555"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016555","sets":["168:169"]},"author_link":["142254"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-03-13","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-03-23"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（保健学）","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Health Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Bone and muscle mass loss are known to occur simultaneously. The alpha-actinin three (ACTN3) genotype has been shown to potentially affect bone and muscle mass. In this study, we investigated the association between the ACTN3 genotype and bone and muscle mass loss in community-dwelling adults aged ≥ 60 years. This study was a cross-sectional analysis of data from 295 participants who participated in a community health checkup. The ACTN3 genotypes were classified as RR, RX, or XX types. Bone mass loss was defined as a calcaneal speed of sound T-score of <−1.32 and <−1.37, and muscle mass loss was defined as an appendicular skeletal muscle index of <7.0 kg/m2 and <5.7 kg/m2 in men and women, respectively. The percentages of XX, RX, and RR in the combined bone and muscle mass loss group were 33.8%, 30.8%, and 16.7%, respectively, with a significantly higher trend for XX. Multinomial logistic regression analysis showed that XX had an odds ratio of 3.00 (95% confidence interval 1.05–8.54) of being in the combined bone and muscle mass loss group compared to the RR group (covariates: age, sex, grip strength, and medications). The ACTN3 genotype of XX is associated with a higher rate of comorbid bone and muscle mass loss. Therefore, ACTN3 genotyping should be considered for preventing combined bone and muscle mass loss.\n\nYoshiaki Taniguchi, Hyuma Makizako, Yuki Nakai, Yuto Kiuchi, Shoma Akaida, Mana Tateishi, Toshihiko Takenaka, Takuro Kubozono and Mitsuru Ohishi\nAssociations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults\nJournal of Clinical Medicine 2022, 11, 6172\nhttps://doi.org/10.3390/jcm11206172","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲保研第34号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"【指導教員：牧迫飛雄馬】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2022-11-11"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷口, 善昭","creatorNameLang":"ja"},{"creatorName":"タニグチ, ヨシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"Diss_谷口善昭_HOK034_2022.pdf","filesize":[{"value":"389.4 kB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_谷口善昭_HOK034_2022","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16555/files/Diss_谷口善昭_HOK034_2022.pdf"},"version_id":"a81989de-8037-481b-992b-bcba4a5285ce"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"Abstract_谷口善昭_4720700058_2022.pdf","filesize":[{"value":"145.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract_谷口善昭_4720700058_2022","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/16555/files/Abstract_谷口善昭_4720700058_2022.pdf"},"version_id":"8b6d164d-23a5-42a4-8350-25b11112b44a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-20"}],"displaytype":"detail","filename":"Result_TANIGUCHI_Yoshiaki_hok_34.pdf","filesize":[{"value":"121.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result_TANIGUCHI_Yoshiaki_hok_34","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16555/files/Result_TANIGUCHI_Yoshiaki_hok_34.pdf"},"version_id":"641e3bbf-08fc-4a0c-937a-50c53133d281"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-20"}],"displaytype":"detail","filename":"Comments_TANIGUCHI_Yoshiaki_hok_34.pdf","filesize":[{"value":"64.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Comments_TANIGUCHI_Yoshiaki_hok_34","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/16555/files/Comments_TANIGUCHI_Yoshiaki_hok_34.pdf"},"version_id":"12b900be-22e5-4ba2-8ed7-ae6259f3fcd7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ACTN3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoporosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sarcopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteosarcopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Associations of the alpha-actinin three genotype with bone and muscle mass loss among middle-aged and older adults","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Associations of the alpha-actinin three genotype with bone and muscle mass loss among middle-aged and older adults","subitem_title_language":"en"},{"subitem_title":"中高齢者におけるα-アクチニン3遺伝子多型と骨量および筋量低下との関連性","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"18","path":["169"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-15"},"publish_date":"2023-03-15","publish_status":"0","recid":"16555","relation_version_is_last":true,"title":["Associations of the alpha-actinin three genotype with bone and muscle mass loss among middle-aged and older adults"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-08T23:56:29.636402+00:00"}