{"created":"2023-07-25T08:15:21.472470+00:00","id":16658,"links":{},"metadata":{"_buckets":{"deposit":"04d711d2-4782-4b03-9cc0-5a86c9dc6ce5"},"_deposit":{"created_by":29,"id":"16658","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"16658"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016658","sets":["57:78"]},"author_link":["142800","142801","142802","142803","142804","142805","142806","142807","142808","142809","142810","142811","142812","142813","142814","142815","142816"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"2049","bibliographicPageStart":"2040","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Translational Cancer Research","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2022-07-30","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background: Gene methylation is deeply involved in epigenetics and affects both the development and maintenance of homeostasis and carcinogenesis. ALKBH4 is a member of the AlkB homolog (ALKBH) family that controls demethylation of DNA and RNA.\nMethods: This study enrolled 160 patients with non-small cell lung cancer (NSCLC) who underwent complete resection. The expression of ALKBH4 in cancer tissue was evaluated by immunohistochemistry. The correlation among the expression of ALKBH4, clinicopathological factors, and prognostic outcome was evaluated.\nResults: In the NSCLC clinical samples, the expression of ALKBH4 was identified not only in cell membranes but also in the cytoplasm of cancer cells. In 140 of 160 cases, ALKBH4 was more highly expressed in the cancerous tissue than in the surrounding normal tissue. The proportion of cancer cells expressing ALKBH4 was higher in adenocarcinoma than in other histological types. In addition, the expression intensity of ALKBH4 in each cancer cell was also stronger in adenocarcinoma than in squamous cell carcinoma. The expression of ALKBH4 was not associated with clinicopathological factors, except for histological type. In adenocarcinoma, the recurrence-free survival (RFS) and overall survival (OS) rates were significantly lower in the ALKBH4-positive group than in the ALKBH4-negative group (P=0.008, 0.031, respectively). A multivariate logistic regression analysis indicated that the ALKBH4 expression was an independent prognostic factor for RFS (P=0.003) and OS (P=0.013). The expression of ALKBH4 was observed in all four patients with adenocarcinoma in situ.\nConclusions: The ALKBH4 expression may be a useful predictor of the postoperative outcomes of lung adenocarcinoma (LUAD) patients.\n\nMasaya Aoki, Kazuhiro Ueda, Go Kamimura, Yoshiyuki Iwamoto, Mizuki Ikehata, Keisuke Tabata, Yuri Sakagami, Shoichiro Morizono, Takuya Tokunaga, Tadashi Umehara, Aya Harada-Takeda, Koki Maeda, Toshiyuki Nagata, Kota Kariatsumari, Tatsuhiko Furukawa, Kazutake Tsujikawa, Masami Sato\nClinical significance of ALKBH4 expression in non-small cell lung cancer\nTranslational Cancer Research 2022;11(7):2040-2049\nhttps://dx.doi.org/10.21037/tcr-22-39","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"AME Publishing Company","subitem_publisher_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2218676X","subitem_source_identifier_type":"PISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aoki, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueda, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamimura, Go","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwamoto, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikehata, Mizuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tabata, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakagami, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morizono, Shoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umehara, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada－Takeda, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Koki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kariatsumari, Kota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Tatsuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujikawa, Kazutake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Masami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142816","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-05-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2022-07-30"}],"filename":"2218676X_v11(7)_p2040-2049.pdf","filesize":[{"value":"687.0 kB"}],"format":"application/pdf","licensefree":"Copyright©Translational Cancer Research. All rights reserved.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/\nThis article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0).","mimetype":"application/pdf","url":{"label":"2218676X_v11(7)_p2040-2049","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16658/files/2218676X_v11(7)_p2040-2049.pdf"},"version_id":"11e03415-889c-4a6a-98ba-49c73f2315f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ALKBH4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-small cell lung cancer (NSCLC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"complete resection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of ALKBH4 expression in non-small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of ALKBH4 expression in non-small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"6","owner":"29","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-05-11"},"publish_date":"2023-05-11","publish_status":"0","recid":"16658","relation_version_is_last":true,"title":["Clinical significance of ALKBH4 expression in non-small cell lung cancer"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-01-10T08:52:54.693847+00:00"}