{"created":"2023-07-25T08:15:22.437699+00:00","id":16680,"links":{},"metadata":{"_buckets":{"deposit":"291c3f26-590d-4e3b-b996-3b433b9529e7"},"_deposit":{"created_by":18,"id":"16680","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"16680"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00016680","sets":["82:130"]},"author_link":["142963","142964","142965","142966","142967","142968","142969","142970","142971","142972"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"174","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Molecular and Clinical Oncology","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-09","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Highly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein (hs‑AFP‑L3) is a specific marker for hepatocellular carcinoma (HCC) and has been reliable in cases with a low serum α‑fetoprotein (AFP) level. However, the biomarkers that contribute to hepatocarcinogenesis during the long‑term observation are not yet clear. The present study reported the clinical utility of hs‑AFP‑L3 in the long‑term observation of patients with chronic liver disease. The subjects were 106 patients with chronic liver disease without HCC or a history of HCC treatment and who had been followed for >12 months. hs‑AFP‑L3 was measured using cryopreserved serum. The factors contributing to hepatocarcinogenesis were examined using univariate and multivariate analyses. The median observation period was 88 months (15‑132 months). The cumulative incidence of HCC was 10.5% at 5 years and 19.6% at 10 years. The univariate analysis revealed that age ≥55 years old, platelet count ≤13.1x104/µl, hyaluronic acid ≥80.8 ng/ml, alanine transaminase ≥47 U/l, AFP ≥6.3 ng/ml, hs‑AFP‑L3 ≥3.5% and des‑γ‑carboxy prothrombin (DCP) ≥25 mAU/ml were significant factors. In the multivariate analysis, platelet count ≤13.1x104/µl [hazard ratio (HR), 4.966; 95% confidence interval (CI), 1.597‑15.437; P=0.006] and hs‑AFP‑L3 ≥3.5% (HR, 5.450; 95% CI, 1.522‑19.512; P=0.009) were extracted as significant factors contributing to hepatocarcinogenesis. In addition, for cases with AFP <20 ng/ml, a multivariate analysis revealed that hs‑AFP‑L3 ≥4.9% (HR, 11.608; 95% CI, 2.422‑55.629; P=0.002) and DCP ≥25 mAU/ml (HR, 3.936; 95% CI, 1.088‑14.231; P=0.037) were significant factors contributing to hepatocarcinogenesis. hs‑AFP‑L3 is a useful marker for predicting hepatocarcinogenesis in the long‑term observation of patients with chronic liver disease.\n\nKazuaki Tabu, Seiichi Mawatari, Kohei Oda, Ohki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kotaro Kumagai, Shuji Kanmura, Akio Ido\nHighly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein is a predictive marker for hepatocarcinogenesis in long‑term observation of patients with chronic liver disease\nMOLECULAR AND CLINICAL ONCOLOGY 15: 174, 2021\nhttps://doi.org/10.3892/mco.2021.2336","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20499450","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12610944","subitem_source_identifier_type":"NCID"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tabu, Kazuaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mawatari, Seiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniyama, Ohki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyodome, Ai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ijuin, Sho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakae, Haruka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumagai, Kotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanmura, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ido, Akio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"142972","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-06-16"}],"displaytype":"detail","filename":"20499450_15_174.pdf","filesize":[{"value":"748.5 kB"}],"format":"application/pdf","licensefree":"Copyright © Tabu et al. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20499450_15_174","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/16680/files/20499450_15_174.pdf"},"version_id":"61d4c5a8-b399-43ab-b667-7d1d86de11e7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α‑fetoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"highly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocarcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic liver disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Highly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein is a predictive marker for hepatocarcinogenesis in long‑term observation of patients with chronic liver disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Highly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein is a predictive marker for hepatocarcinogenesis in long‑term observation of patients with chronic liver disease","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["130"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-16"},"publish_date":"2023-06-16","publish_status":"0","recid":"16680","relation_version_is_last":true,"title":["Highly sensitive Lens culinaris agglutinin‑reactive fraction of α‑fetoprotein is a predictive marker for hepatocarcinogenesis in long‑term observation of patients with chronic liver disease"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:33:15.360442+00:00"}