{"created":"2023-09-26T06:29:00.091612+00:00","id":2000003,"links":{},"metadata":{"_buckets":{"deposit":"fb0214e1-b7c5-46ae-b049-7e75aa5af63d"},"_deposit":{"created_by":29,"id":"2000003","owner":"29","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000003"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000003","sets":["57:86"]},"author_link":["143840"],"control_number":"2000003","item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-07-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-07-19"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Objective: Autoimmune autonomic ganglionopathy (AAG) is a rare disorder characterized by autonomic failure associated with the presence of anti-ganglionic acetylcholine receptor (gAChR) antibodies; however, several studies have reported that individuals with anti-gAChR antibodies present with central nervous system (CNS) symptoms such as impaired consciousness and seizures. In the present study, we investigated whether the presence of serum anti-gAChR antibodies correlated with autonomic symptoms in patients with functional neurological symptom disorder/conversion disorder (FNSD/CD).\nMethods: Clinical data were collected for 59 patients presenting with neurologically unexplained motor and sensory symptoms at the Department of Neurology and Geriatrics between January 2013 and October 2017 and who were ultimately diagnosed with FNSD/CD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Correlations between serum anti-gAChR antibodies and clinical symptoms and laboratory data were analyzed. Data analysis was conducted in 2021.\nResults: Of the 59 patients with FNSD/CD, 52 (88.1%) exhibited autonomic disturbances and 16 (27.1%) were positive for serum anti-gAChR antibodies. Cardiovascular autonomic dysfunction, including orthostatic hypotension, was significantly more prevalent (75.0 vs. 34.9%, P = 0.008), whereas involuntary movements were significantly less prevalent (31.3 vs. 69.8%, P = 0.007), among anti-gAChR antibody-positive compared with -negative patients. Anti-gAChR antibody serostatus did not correlate significantly with the frequency of other autonomic, sensory, or motor symptoms analyzed.\nConclusions: An autoimmune mechanism mediated by anti-gAChR antibodies may be involved in disease etiology in a subgroup of FNSD/CD patients.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Ryusei Nagata, Eiji Matsuura, Satoshi Nozuma, Mika Dozono, Yutaka Noguchi, Masahiro Ando, Yu Hiramatsu, Daisuke Kodama, Masakazu Tanaka, Ryuji Kubota, Munekazu Yamakuchi, Yujiro Higuchi, Yusuke Sakiyama, Hitoshi Arata, Keiko Higashi, Teruto Hashiguchi, Shunya Nakane and Hiroshi Takashima\nAnti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder\nFrontiers in Neurology 14:1137958.\nhttps://doi.org/10.3389/fneur.2023.1137958","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第706号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:髙嶋博】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-05-10"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永田, 龍世","creatorNameLang":"ja"},{"creatorName":"ナガタ, リュウセイ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagata, Ryusei","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{"nameIdentifier":"143840","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-03"}],"displaytype":"detail","filename":"Diss_永田_龍世_ISK706_2023.pdf","filesize":[{"value":"425 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_永田_龍世_ISK706_2023","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000003/files/Diss_永田_龍世_ISK706_2023.pdf"},"version_id":"dae25a5e-f96f-4b05-9d07-2dfe839aa7db"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-03"}],"displaytype":"detail","filename":"Abstract_永田_龍世_4515810142_2023.pdf","filesize":[{"value":"128 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_永田_龍世_4515810142_2023","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000003/files/Abstract_永田_龍世_4515810142_2023.pdf"},"version_id":"18e45171-aea0-4a2d-903f-6bce7e4cbdef"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-26"}],"displaytype":"detail","filename":"Result_NAGATA_Ryusei_isk_706.pdf","filesize":[{"value":"143 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000003/files/Result_NAGATA_Ryusei_isk_706.pdf"},"version_id":"2ada9267-6a5c-488c-816e-3e5c0e80d1a5"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-26"}],"displaytype":"detail","filename":"Comments_NAGATA_Ryusei_isk_706.pdf","filesize":[{"value":"55 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000003/files/Comments_NAGATA_Ryusei_isk_706.pdf"},"version_id":"211d6fb8-736f-4e14-91c8-562c4c2bc124"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"autonomic symptoms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"functional neurological symptom disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conversion disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ganglionic acetylcholine receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LIPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Anti-ganglionic acetylcholine receptor antibodies in Functional Neurological Symptom Disorder/Conversion Disorderr","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-ganglionic acetylcholine receptor antibodies in Functional Neurological Symptom Disorder/Conversion Disorderr","subitem_title_language":"en"},{"subitem_title":"機能性神経症状症/転換性障害では抗ganglionic acetylcholine receptor抗体の陽性率が高い","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-26"},"publish_date":"2023-09-26","publish_status":"0","recid":"2000003","relation_version_is_last":true,"title":["Anti-ganglionic acetylcholine receptor antibodies in Functional Neurological Symptom Disorder/Conversion Disorderr"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2024-07-03T04:25:34.200999+00:00"}