{"created":"2023-09-28T02:03:01.601811+00:00","id":2000019,"links":{},"metadata":{"_buckets":{"deposit":"f72e0a4e-97db-4859-8a32-9a143dc61860"},"_deposit":{"created_by":29,"id":"2000019","owner":"29","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000019"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000019","sets":["57:86"]},"author_link":["143852"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-09-15","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-09-29"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background\nPredicting metabolic syndrome (MetS) is important for identifying high-risk cardiovascular disease individuals and providing preventive interventions. We aimed to develop and validate an equation and a simple MetS score according to the Japanese MetS criteria.\nMethods\nIn total, 54,198 participants (age, 54.5±10.1 years; men, 46.0%), with baseline and 5-year follow-up data were randomly assigned to ‘Derivation’ and ‘Validation’ cohorts (ratio: 2:1). Multivariate logistic regression analysis was performed in derivation cohort and scores were assigned to factors corresponding to β-coefficients. We evaluated predictive ability of the scores using area under the curve (AUC), then applied them to validation cohort to assess reproducibility.\nResults\nThe primary model ranged 0–27 points had an AUC of 0.81 (sensitivity: 0.81, specificity: 0.81, cut-off score: 14), and consisted of age, sex, blood pressure (BP), body mass index (BMI), serum lipids, glucose measurements, tobacco smoking, and alcohol consumption. The simplified model (excluding blood tests) ranged 0–17 points with an AUC of 0.78 (sensitivity: 0.83, specificity: 0.77, cut-off score: 15) and included: age, sex, systolic BP, diastolic BP, BMI, tobacco smoking, and alcohol consumption. We classified individuals with a score <15 and ≥15 points as low- and high-risk MetS, respectively. Furthermore, the equation model generated an AUC of 0.85 (sensitivity: 0.86, specificity: 0.55). Analysis of the validation and derivation cohorts yielded similar results.\nConclusion\nWe developed a primary score, an equation model, and a simple score. The simple score is convenient, well-validated with acceptable discrimination, and could be used for early detection of MetS in high-risk individuals.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Anwar Ahmed Salim ,Shin Kawasoe ,Takuro Kubozono  ,Satoko Ojima ,Takeko Kawabata ,Hiroshi Hashiguchi ,Yoshiyuki Ikeda ,Masaaki Miyata ,Hironori Miyahara ,Koichi Tokushige ,Yoshihiko Nishio ,Mitsuru Ohishi\nDevelopment of predictive equation and score for 5-year metabolic syndrome incidence in Japanese adults\nPLoS ONE 18(4): e0284139\nhttps://doi.org/10.1371/journal.pone.0284139","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第714号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"PLOS","subitem_publisher_language":"en"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:大石充】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-05-10"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Anwar Ahmed Salim","creatorNameLang":"en"}],"givenNames":[{"givenName":"Anwar Ahmed Salim","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"143852","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-24"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2023-09-15"}],"filename":"Diss_Anwar_Ahmed_Salim_ISK714_2023.pdf","filesize":[{"value":"1.7 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KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_Anwar_Ahmed_Salim_isk_714.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000019/files/Comments_Anwar_Ahmed_Salim_isk_714.pdf"},"version_id":"2f46d251-7082-4fe3-b142-35b85ba07833"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Development of Predictive Equation and Score for 5-Year Metabolic Syndrome Incidence in Japanese Adults","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Predictive Equation and Score for 5-Year Metabolic Syndrome Incidence in Japanese Adults","subitem_title_language":"en"},{"subitem_title":"日本人成人における５年後のメタボリックシンドローム発症の予測式およびスコアの作成","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-28"},"publish_date":"2023-09-28","publish_status":"0","recid":"2000019","relation_version_is_last":true,"title":["Development of Predictive Equation and Score for 5-Year Metabolic Syndrome Incidence in Japanese Adults"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-06-24T01:49:32.292537+00:00"}