{"created":"2024-01-24T08:36:22.549617+00:00","id":2000090,"links":{},"metadata":{"_buckets":{"deposit":"645ef34f-fb0e-42a0-b594-17ff16932253"},"_deposit":{"created_by":29,"id":"2000090","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000090"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000090","sets":["57:86"]},"author_link":["143898"],"control_number":"2000090","item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2023-12-18","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2023-12-26"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Spinal cord injury (SCI) is a devastating neurologic disorder that often leads to permanent disability, and there is no effective treatment for it. High mobility group box-1 (HMGB1) is a damage-associated molecular protein that triggers sterile inflammation upon injuries. We have previously shown that two administrations of neutralizing monoclonal antibody (mAb) against HMGB1 (immediately after (0 h) and 6 h after) SCI dramatically improves functional recovery after SCI in mice. However, when considering clinical application, 0 h after SCI is not practical. Therefore, in this study, we examined the therapeutic time window of the mAb administration. Injection at 3 h after SCI significantly improved the functional recovery comparably to injection immediately after SCI, while injection at 6 h was less effective, and injection at 9 or 12 h had no therapeutic effect. We also found beneficial effects of injection at 3 h after injury on blood-spinal cord barrier maintenance, inflammatory-related gene expression and preservation of the damaged spinal cord tissue. Taken together, our results suggest that a single administration of anti-HMGB1 mAb within a proper time window could be a novel and potential therapeutic strategy for SCI.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Masahide Nakajo, Naohiro Uezono, Hideyuki Nakashima, Hidenori Wake, Setsuro Komiya, Masahiro Nishibori, Kinichi Nakashima\nTherapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury\nNeuroscience Research,Volume 141,2019,Pages 63-70\nhttps://doi.org/10.1016/j.neures.2018.03.004","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙総論第48号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:谷口昇】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-05-10"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Masahide","creatorNameLang":"en"}],"familyNames":[{"familyName":"中條","familyNameLang":"ja"},{"familyName":"ナカジョウ","familyNameLang":"ja-Kana"},{"familyName":"Nakajo","familyNameLang":"en"}],"givenNames":[{"givenName":"正英","givenNameLang":"ja"},{"givenName":"マサヒデ","givenNameLang":"ja-Kana"},{"givenName":"Masahide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"143898","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2023-12-18"}],"filename":"Diss_NAKAJO_Masahide_ISK48_2023.pdf","filesize":[{"value":"2.2 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injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HMGB1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Time window","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood-spinal-cord barrier","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury","subitem_title_language":"en"},{"subitem_title":"急性期脊髄損傷に対する抗HMGB１抗体療法とTime windowに関して","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-24"},"publish_date":"2024-01-24","publish_status":"0","recid":"2000090","relation_version_is_last":true,"title":["Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T01:38:20.549380+00:00"}