{"created":"2024-02-08T06:41:25.979352+00:00","id":2000133,"links":{},"metadata":{"_buckets":{"deposit":"66044d49-8674-4218-b829-b769f789c59a"},"_deposit":{"created_by":29,"id":"2000133","owner":"18","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000133"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000133","sets":["57:86"]},"author_link":["143919"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-01-24","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-01-31"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"MicroRNAs (miRNAs) have attracted attention as non-invasive cancer biomarkers in various cancers; however, they have not been adequately investigated in oral squamous cell carcinoma (OSCC). This study investigated the diagnostic performance of serum-derived miRNAs at initial diagnosis for primary neck lymph node metastasis and the predictive performance for late neck lymph node metastasis based on long-term (up to approximately 8 years) follow-up of patients with OSCC. The expression of miRNAs in 40 patients with OSCC was quantified using real-time PCR (qPCR), and a comprehensive statistical analysis of the correlation of miRNA expression for primary and late neck lymph node metastases was performed. For the diagnosis of primary neck lymph node metastases, miR-423 and miR-125 were accurate. The miRNA index for primary metastasis diagnosis (miR-PM) calculated by regression analysis showed high diagnostic accuracy. The miR-5100 was useful for predicting late neck lymph node metastases. The miRNA index for late metastasis prediction (miR-LM) calculated using regression analysis showed high prediction accuracy. MiRNAs were useful for diagnosing primary neck lymph node metastases in OSCC and predicting late neck lymph node metastases. It may help to consider individualized treatment, including follow-up, surgical methods, and postoperative management.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Higashi, Yutaro, Kodai Nakamura, Ryota Takaoka, Mika Tani, Yusaku Noma, Kazuki Mori, Kota Yamashiro, Seiya Yokoyama, Tomofumi Hamada, and Tsuyoshi Sugiura\nIdentification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis\nCancers 2023, 15, 3769.\nhttps://doi.org/10.3390/cancers15153769","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第719号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:杉村光隆】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-11-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Yutaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"東","familyNameLang":"ja"},{"familyName":"ヒガシ","familyNameLang":"ja-Kana"},{"familyName":"Higashi","familyNameLang":"en"}],"givenNames":[{"givenName":"友太郎","givenNameLang":"ja"},{"givenName":"ユウタロウ","givenNameLang":"ja-Kana"},{"givenName":"Yutaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"143919","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-01-24"}],"filename":"Diss_HIGASHI_Yutaro_ISK719_2023.pdf","filesize":[{"value":"3.1 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cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oral squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor marker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neck lymph node metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"},{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis","subitem_title_language":"en"},{"subitem_title":"頸部リンパ節転移特異的microRNAの同定-頸部リンパ節転移のモニタリング、予測への応用","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-08"},"publish_date":"2024-02-08","publish_status":"0","recid":"2000133","relation_version_is_last":true,"title":["Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-07-02T00:03:02.987828+00:00"}