{"created":"2024-02-29T02:23:12.679535+00:00","id":2000152,"links":{},"metadata":{"_buckets":{"deposit":"3d24e506-2233-4d49-8cba-a4ca4ed1de2f"},"_deposit":{"created_by":29,"id":"2000152","owner":"18","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000152"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000152","sets":["57:86"]},"author_link":["143928"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-02-13","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-02-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background\nUpon cellular injury, damage-associated molecular patterns (DAMPs) are released into the extracellular space and evoke proinflammatory and prothrombotic responses in animal models of sterile inflammation. However, in clinical settings, the dynamics of DAMP levels after trauma and links between DAMPs and trauma-associated coagulopathy remain largely undetermined.\nMethods\nThirty-one patients with severe trauma, who were transferred to Kagoshima City Hospital between June 2018 and December 2019, were consecutively enrolled in this study. Blood samples were taken at the time of delivery, and 6 and 12 h after the injury, and once daily thereafter. The time-dependent changes of coagulation/fibrinolysis markers, including thrombin-antithrombin complex, α2-plasmin inhibitor (α2-PI), plasmin-α2-PI complex, and plasminogen activator inhibitor-1 (PAI-1), and DAMPs, including high mobility group box 1 and histone H3, were analyzed. The relationship between coagulation/fibrinolysis markers, DAMPs, Injury Severity Score, in-hospital death, and amount of blood transfusion were analyzed.\nResults\nThe activation of coagulation/fibrinolysis pathways was evident at the time of delivery. In contrast, PAI-1 levels remained low at the time of delivery, and then were elevated at 6–12 h after traumatic injury. Histone H3 and high mobility group box 1 levels were elevated at admission, and gradually subsided over time. PAI-1 levels at 6 h were associated with serum histone H3 levels at admission. Increased histone H3 levels and plasmin-α2-PI complex levels were associated with in-hospital mortality. α2-PI levels at admission showed the strongest negative correlation with the amount of blood transfusion.\nConclusion\nThe elevation of histone H3 levels and fibrinolysis perturbation are associated with fatal outcomes in patients with traumatic injury. Patients with low α2-PI levels at admission tend to require blood transfusion.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Kenshin Shimono, Takashi Ito, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Hirokazu Onishi, Hideaki Yoshihara, Ikuro Maruyama & Yasuyuki Kakihana \nDamage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury\nThrombosis Journal (2023) 21:91\nhttps://doi.org/10.1186/s12959-023-00536-w","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第721号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:垣花泰之】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-10-04"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下野, 謙慎","creatorNameLang":"ja"},{"creatorName":"シモノ, ケンシン","creatorNameLang":"ja-Kana"},{"creatorName":"Shimono, Kenshin","creatorNameLang":"en"}],"familyNames":[{"familyName":"下野","familyNameLang":"ja"},{"familyName":"シモノ","familyNameLang":"ja-Kana"},{"familyName":"Shimono","familyNameLang":"en"}],"givenNames":[{"givenName":"謙慎","givenNameLang":"ja"},{"givenName":"ケンシン","givenNameLang":"ja-Kana"},{"givenName":"Kenshin","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"143928","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Diss_SHIMONO_Kenshin_ISK721_2023.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_SHIMONO_Kenshin_ISK721_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000152/files/Diss_SHIMONO_Kenshin_ISK721_2023.pdf"},"version_id":"32fd2811-3552-49cd-ad5b-1746f535315b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Abstract_SHIMONO_Kenshin_4516810316_2023.pdf","filesize":[{"value":"77.1 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_SHIMONO_Kenshin_4516810316_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000152/files/Abstract_SHIMONO_Kenshin_4516810316_2023.pdf"},"version_id":"115a193d-e853-4e7c-8362-300390cc01ff"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-29"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Result_SHIMONO_Kenshin_isk_721.pdf","filesize":[{"value":"118 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_SHIMONO_Kenshin_isk_721.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000152/files/Result_SHIMONO_Kenshin_isk_721.pdf"},"version_id":"049185de-2143-4c5d-bae8-d1cc1a946675"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-29"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Comments_SHIMONO_Kenshin_isk_721.pdf","filesize":[{"value":"54 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_SHIMONO_Kenshin_isk_721.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000152/files/Comments_SHIMONO_Kenshin_isk_721.pdf"},"version_id":"0c4caaa7-426e-4ac3-a0a7-3202a5921001"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Damage-associated molecular patterns (DAMPs)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Trauma-induced coagulopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Histone H3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmin-α2-PI complex (PIC)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasminogen activator inhibitor-1 (PAI-1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"},{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Damage‑associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Damage‑associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury","subitem_title_language":"en"},{"subitem_title":"外傷患者においてDAMPsと線溶系の変動は予後と関連している","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-29"},"publish_date":"2024-02-29","publish_status":"0","recid":"2000152","relation_version_is_last":true,"title":["Damage‑associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-07-02T00:21:28.177881+00:00"}