{"created":"2024-02-29T02:42:22.397687+00:00","id":2000154,"links":{},"metadata":{"_buckets":{"deposit":"b83042d4-f82b-4662-ba1d-a5fdb81a6c24"},"_deposit":{"created_by":29,"id":"2000154","owner":"18","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000154"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000154","sets":["57:86"]},"author_link":["143930"],"control_number":"2000154","item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-02-13","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-02-20"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文要約, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Purpose\nThis study aims to investigate changes in the tumor immune environment of patients who underwent therapy with a vascular endothelial growth factor (VEGF) inhibitor for advanced colorectal cancer.\nMethods\nPatients (n = 135) with T3 or T4 colorectal cancer were included in this retrospective study. They were classified as follows: patients who had not received preoperative treatment (UPFRONT group, n = 54), who had received FOLFOX as preoperative chemotherapy (FOLFOX group, n = 55), and who had undergone resection after combination FOLFOX and bevacizumab as unresectable colorectal cancer (B-MAB group, n = 26). The number of cytotoxic T lymphocytes (CTLs), FOXP3+ lymphocytes (including regulatory T cells (Tregs)), CD163+ monocytes (including M2-type tumor-associated macrophages (TAM-M2 type)), and programmed cell death 1 (PD-1)+ lymphocytes was evaluated immunohistochemically in the cancer cell area (CC) and stromal cell area (ST) of surgical specimens, and compared among the three groups.\nResults\nThe CTL population did not differ among the three groups in both areas. In the B-MAB group, the numbers of PD-1+ cells in the ST, FOXP3+ lymphocytes in both areas, and CD163+monocytes in the ST was lower than that in the other two groups, and a correlation with the histological therapeutic effect was observed.\nConclusions\nIn advanced colorectal cancer, VEGF inhibitors may decrease the number of PD-1+ cells and inhibit the infiltration of FOXP3+ lymphocytes and CD163+monocytes into the tumor environment.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Yuki Hamada, Kiyonori Tanoue, Yoshiaki Kita, Kan Tanabe, Kentaro Hokonohara, Masumi Wada, Yuto Hozaka, Hideyuki Oi, Chieri Nakayama, Michiyo Higashi, Takaaki Arigami, Shinichiro Mori & Takao Ohtsuka\nVascular Endothelial Growth Factor Inhibitors Promote Antitumor Responses via Tumor Microenvironment Immunosuppression in Advanced Colorectal Cancer\nScandinavian Journal of Gastroenterology 58 (9): 1009–1020 2023\nhttps://doi.org/10.1080/00365521.2023.2194011","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"This is an Accepted Manuscript of an article published by Taylor & Francis in Scandinavian Journal of Gastroenterology on 29 Mar 2023, available at: https://doi.org/10.1080/00365521.2023.2194011","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第723号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:大塚隆生】要約公表の理由: 多重公表を禁止するジャーナルへの投稿論文であるため"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-11-01"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濵田, 由紀","creatorNameLang":"ja"},{"creatorName":"ハマダ, ユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamada, Yuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"濵田","familyNameLang":"ja"},{"familyName":"ハマダ","familyNameLang":"ja-Kana"},{"familyName":"Hamada","familyNameLang":"en"}],"givenNames":[{"givenName":"由紀","givenNameLang":"ja"},{"givenName":"ユキ","givenNameLang":"ja-Kana"},{"givenName":"Yuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"143930","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Digest_HAMADA_Yuki_ISK723_2023.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Digest_HAMADA_Yuki_ISK723_2023.pdf","objectType":"summary","url":"https://ir.kagoshima-u.ac.jp/record/2000154/files/Digest_HAMADA_Yuki_ISK723_2023.pdf"},"version_id":"e149c518-9c8e-4bbc-a7e1-dafbac5304c0"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-07-02"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Abstract_HAMADA_Yuki_4519810276_2023.pdf","filesize":[{"value":"231.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_HAMADA_Yuki_4519810276_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000154/files/Abstract_HAMADA_Yuki_4519810276_2023.pdf"},"version_id":"bda26df3-f05a-48d2-9064-1237a1f07c05"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-29"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Result_HAMADA_Yuki _isk_723.pdf","filesize":[{"value":"140 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_HAMADA_Yuki _isk_723.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000154/files/Result_HAMADA_Yuki _isk_723.pdf"},"version_id":"e9f7ab5f-8723-4ec8-bf1e-95182a9fc21f"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-29"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-02-13"}],"filename":"Comments_HAMADA_Yuki _isk_723.pdf","filesize":[{"value":"54 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_HAMADA_Yuki _isk_723.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000154/files/Comments_HAMADA_Yuki _isk_723.pdf"},"version_id":"dac6bfc7-d114-45f0-8860-716767664f8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular endothelial growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bevacizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regulatory T cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"M2-type tumor-associated macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"programmed cell death 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"},{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Vascular endothelial growth factor inhibitors promote antitumor responses via tumor microenvironment immunosuppression in advanced colorectal cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vascular endothelial growth factor inhibitors promote antitumor responses via tumor microenvironment immunosuppression in advanced colorectal cancer","subitem_title_language":"en"},{"subitem_title":"VEGF 阻害剤は進行大腸癌患者において腫瘍微小環境の免疫抑制応答を調節することにより抗腫瘍免疫応答を促進する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-29"},"publish_date":"2024-02-29","publish_status":"0","recid":"2000154","relation_version_is_last":true,"title":["Vascular endothelial growth factor inhibitors promote antitumor responses via tumor microenvironment immunosuppression in advanced colorectal cancer"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T02:34:39.314574+00:00"}