{"created":"2024-05-24T02:02:11.030703+00:00","id":2000342,"links":{},"metadata":{"_buckets":{"deposit":"dec37bb9-61b2-4eaa-9476-642a517d4c29"},"_deposit":{"created_by":29,"id":"2000342","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000342"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000342","sets":["82:130"]},"author_link":["1301","144118","144121","144119","116819","116821","118791"],"control_number":"2000342","item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1125","bibliographicPageStart":"1116","bibliographicVolumeNumber":"187","bibliographic_titles":[{"bibliographic_title":"Journal of Infectious Diseases","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-04-01","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Human T cell lymphotropic virus type I (HTLV-I) provirus load has been reported to be generally higher in patients with HTLV-I–associated myelopathy/tropical spastic paraparesis (HAM/TSP) than in asymptomatic HTLV-I carriers (ACs). However, some ACs have a high HTLV-I provirus load comparable with that in patients with HAM/TSP. To examine whether other factors influence the outcome of HTLV-I infection in patients with HAM/TSP and ACs, we analyzed spontaneous Tax expression and cytokine production in peripheral blood mononuclear cells using flow cytometry. The Tax expression in HTLV-I–infected cells (percentage of Tax expressing cells/HTLV-I provirus load when assumed 1 copy/cell) and the intensity of Tax expression did not differ between these 2 groups. However, the production of interferon-γ and tumor necrosis factor–α in Tax-expressing cells was significantly lower in ACs with high HTLV-I provirus load than in patients with HAM/TSP. This result suggests that the production of inflammatory cytokines in Tax-expressing cells is one of the factors that contribute to the development of HAM/TSP","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"This is a pre-copyedited, author-produced version of an article accepted for publication in [ Journal of Infectious Diseases ] following peer review. The version of record \n[ Yoshitaka Furukawa, Mineki Saito, Wataru Matsumoto, Koichiro Usuku, Yuetsu Tanaka, Shuji Izumo, Mitsuhiro Osame\nDifferent Cytokine Production in Tax-Expressing Cells between Patients with Human T Cell Lymphotropic Virus Type I (HTLV-I)–Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic HTLV-I Carriers\nThe Journal of Infectious Diseases, Volume 187, Issue 7, 1 April 2003, Pages 1116–1125 ] \nis available online at: https://doi.org/10.1086/368379\nhttps://academic.oup.com/jid/article/187/7/1116/800443?login=true","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University 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