{"created":"2024-05-24T02:02:11.039823+00:00","id":2000343,"links":{},"metadata":{"_buckets":{"deposit":"9d4c72ac-0777-4acd-9fe7-7258ea719d8b"},"_deposit":{"created_by":29,"id":"2000343","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000343"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000343","sets":["82:130"]},"author_link":["1301","144119","116821","118791"],"control_number":"2000343","item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1099","bibliographicPageStart":"1092","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"AIDS Research and Human Retroviruses","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-10-18","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The function of the p12I protein of human T cell lymphotropic virus type I (HTLV-I) has been under debate. p12K (lysine) and p12R (arginine) variants of this protein at amino acid 88 and a shorter life of p12K had been reported by another group. Because HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients usually have a higher provirus load than asymptomatic HTLV-I carriers (ACs), and p12I had been suggested to confer a proliferative effect on HTLV-I-infected cells in vitro, it is possible that the relatively unstable p12K is less frequent in HAM/TSP patients than in ACs. To elucidate whether p12K and other alterations in the p12 gene were related to the outcome of HTLV-I infection, we sequenced the p12 gene in 144 HAM/TSP patients, 41 adult T cell leukemia (ATL) patients, and in 46 ACs. p12K was observed in only two HAM/TSP patients, but was not present in either ATL patients or ACs. Interestingly, a premature termination codon in the p12 was observed in 5.6% of HAM/TSP patients and in 4.9% of ATL patients but none was found in ACs. The p12 initiation codon was destroyed in one HAM/TSP patient. These HTLV-I variants with truncated p12 protein or with a destroyed initiation codon in the p12 gene appeared to have been transmitted in the subjects’ families. These findings suggest that p12 is dispensable for the transmission and maintenance of HTLV-I infection, although it is premature to conclude that sequence varitation in the p12 gene is associated with differences in the outcome of HTLV-I infection.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"This is the accepted version of the following article:\n [ Yoshitaka Furukawa, Koichiro Usuku, Shuji Izumo, and Mitsuhiro Osame\nHuman T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo\nAIDS Research and Human Retroviruses 2004 20:10, 1092-1099 ], \nwhich has now been formally published in final form at [ AIDS Research and Human Retroviruses ] at [ https://doi.org/10.1089/aid.2004.20.1092 \n]. This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Mary Ann Liebert","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1089/aid.2004.20.1092","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"08892229","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10689080","subitem_source_identifier_type":"NCID"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 良尚","creatorNameLang":"ja"},{"creatorName":"Furukawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"1301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usuku, Koichiro","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"144119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumo, Shuji","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"116821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Osame, Mitsuhiro","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"118791","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-05-24"}],"displaytype":"detail","filename":"P12_aids_hr (Revised）.pdf","filesize":[{"value":"295 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"P12_aids_hr (Revised）","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000343/files/P12_aids_hr (Revised）.pdf"},"version_id":"fe1e19e0-8aeb-44b5-aa1c-97caa6ce211a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo","subitem_title_language":"en"}]},"item_type_id":"6","owner":"29","path":["130"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-24"},"publish_date":"2024-05-24","publish_status":"0","recid":"2000343","relation_version_is_last":true,"title":["Human T Cell Lymphotropic Virus Type I (HTLV-I) p12ᴵ Is Dispensable for HTLV-I Transmission and Maintenance of Infection in Vivo"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2024-05-27T06:27:59.124017+00:00"}