{"created":"2024-05-24T02:02:16.715438+00:00","id":2000344,"links":{},"metadata":{"_buckets":{"deposit":"c7fb5c8e-4995-42ba-8172-8f54000f9746"},"_deposit":{"created_by":29,"id":"2000344","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000344"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000344","sets":["82:130"]},"author_link":["1301","120505","116821","144123","118791"],"control_number":"2000344","item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"387","bibliographicPageStart":"381","bibliographicVolumeNumber":"118","bibliographic_titles":[{"bibliographic_title":"International Journal of Cancer","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2005-07-28","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"In the pathogenesis of adult T cell leukemia (ATL), an oncogenetic role of the human T cell lymphotropic virus type I (HTLV-I) Tax protein, viral escape from the host immune system, and host genetic changes have been proposed as contributory factors. We examined the premature stop codons in tax gene as one of the mutations that may lead to escape of HTLV-I from the cytotoxic T lymphocyte (CTL) response in HTLV-I carriers, to test whether a putative CTL escape mutant can emerge in the early stage of ATL development and whether HTLV-I infected cells with such a mutation can proliferate subsequently. We also examined deletion of cyclin-dependent kinase inhibitor 4 (INK4) genes and mutation of p53 gene in combination with changes in the HTLV-I genome in acute type ATL to test whether host genetic changes promoted the malignant transformation of ATL cells that carry putative CTL escape mutations. The premature stop codon in tax gene existed in many non-ATL HTLV-I carriers as a minor population but not in the commonest HTLV-I sequence of the individual. This minor population with a premature stop codon did not expand subsequently in 3 asymptomatic carriers tested. There were cases who had a mutation or deletion in HTLV-I who also have either deletion of INK4 genes or mutation in p53 gene. Our findings suggest that CTL escape mutation can occur at an early stage of ATL development, and that certain host genetic changes favor the development of the aggressive form of ATL.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Yoshitaka Furukawa, Mitsutoshi Tara, Shuji Izumo, Kimiyoshi Arimura, Mitsuhiro Osame\nHTLV-I viral escape and host genetic changes in the development of adult T cell leukemia\nInt. J. Cancer: 118, 381–387 (2006)\nhttps://doi.org/10.1002/ijc.21328","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"This is the peer reviewed version of the following article: [ https://onlinelibrary.wiley.com/doi/10.1002/ijc.21328 ],\n which has been published in final form at [ https://doi.org/10.1002/ijc.21328 ]. \nThis article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/ijc.21328","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10970215","subitem_source_identifier_type":"EISSN"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11621537","subitem_source_identifier_type":"NCID"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 良尚","creatorNameLang":"ja"},{"creatorName":"Furukawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{"nameIdentifier":"1301","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TARA, Mitsutoshi","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"120505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumo, Shuji","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"116821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arimura, Kimiyoshi","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"144123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Osame, Mitsuhiro","creatorNameLang":"en"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{"nameIdentifier":"118791","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-05-24"}],"displaytype":"detail","filename":"IJC-04-2515(Furukawa accepted).pdf","filesize":[{"value":"225 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"IJC-04-2515(Furukawa accepted)","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000344/files/IJC-04-2515(Furukawa accepted).pdf"},"version_id":"c23fdbfc-105d-418f-9396-60e1506c7565"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"viral escape","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"INK4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ATL","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia","subitem_title_language":"en"}]},"item_type_id":"6","owner":"29","path":["130"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-24"},"publish_date":"2024-05-24","publish_status":"0","recid":"2000344","relation_version_is_last":true,"title":["HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2024-05-27T06:38:39.676050+00:00"}