{"created":"2024-06-07T08:35:00.442366+00:00","id":2000351,"links":{},"metadata":{"_buckets":{"deposit":"7cf8c3ff-3214-4ced-b0c1-f8666d51de78"},"_deposit":{"created_by":29,"id":"2000351","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000351"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000351","sets":["57:86"]},"author_link":["144130"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-03-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Ancillary immunohistochemical tools can facilitate an integrated diagnosis of endometrial pathology. According to The Cancer Genome Atlas classification, endometrial cancers are of four molecular subtypes: mismatch repair (MMR)-deficient (MMR-d), p53 mutation (p53mut), DNA polymerase epsilon (POLE) mutation (POLEmut), and no specific molecular profile (NSMP). As the specific histological and immunohistochemical features of POLEmut and NSMP subtypes are unknown, these cancers are categorized based on molecular analysis. In this study, we analyzed POLEmut-subtype endometrioid carcinoma (EC) using a custom-made cancer gene panel and the Catalog of Somatic Mutations in Cancer (COSMIC) database, extracted a characteristic genome profile, and identified an immunohistochemical marker that could be used as a diagnostic tool. The results indicated that the POLEmut-subtype EC exhibited nonsense mutations in the ataxia telangiectasia mutated (ATM) gene and a subsequent loss of ATM expression, which was monitored through immunohistochemical analysis. Moreover, analyses using the COSMIC database indicated that POLEmut-subtype EC cases often harbored similar ATM nonsense mutations. These results suggest that ATM expression is a potential immunohistochemical marker for the differential diagnosis of POLEmut- and NSMP-subtype EC.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Ikumi Kitazono, Yusuke Kobayashi, Toshiaki Akahane, Tomomi Yamaguchi, Shintaro Yanazume, Sachio Nohara, Ippei Sakamoto, Kazuhiro Tabata, Takashi Tasaki, Hiroaki Kobayashi, Akihide Tanimoto\nATM immunohistochemistry as a potential marker for the differential diagnosis of no specific molecular profile subtype and POLE-mutation subtype endometrioid carcinoma\nPathology - Research and Practice, Volume 230, 2022, 153743\nhttps://doi.org/10.1016/j.prp.2021.153743","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第730号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:小林裕明】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-11-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 裕介","creatorNameLang":"ja"},{"creatorName":"Kobayashi, Yusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"小林","familyNameLang":"ja"},{"familyName":"Kobayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"裕介","givenNameLang":"ja"},{"givenName":"Yusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144130","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Diss_KOBAYASHI_Yusuke_ISK730_2023.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Diss_KOBAYASHI_Yusuke_ISK730_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000351/files/Diss_KOBAYASHI_Yusuke_ISK730_2023.pdf"},"version_id":"fc85c7b8-6b6a-4955-af60-b7dfdde097b4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Abstract_KOBAYASHI_Yusuke_4520800049_2023.pdf","filesize":[{"value":"25.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_KOBAYASHI_Yusuke_4520800049_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000351/files/Abstract_KOBAYASHI_Yusuke_4520800049_2023.pdf"},"version_id":"b6198609-e2ff-4abf-86c6-cae735b86660"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Result_KOBAYASHI_Yusuke_isk_730.pdf","filesize":[{"value":"173 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_KOBAYASHI_Yusuke_isk_730","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000351/files/Result_KOBAYASHI_Yusuke_isk_730.pdf"},"version_id":"52670364-7763-4167-979e-822f5853b878"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Comments_KOBAYASHI_Yusuke_isk_730.pdf","filesize":[{"value":"150 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_KOBAYASHI_Yusuke_isk_730","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000351/files/Comments_KOBAYASHI_Yusuke_isk_730.pdf"},"version_id":"799c5094-8546-444c-be7f-d90463bf8a14"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Endometrial cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"POLE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ATM","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"COSMIC database","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NGS","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"ATM immunohistochemistry as a potential marker for the differential diagnosis of no specific molecular profile subtype and POLE-mutation subtype endometrioid carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ATM immunohistochemistry as a potential marker for the differential diagnosis of no specific molecular profile subtype and POLE-mutation subtype endometrioid carcinoma","subitem_title_language":"en"},{"subitem_title":"ATM免疫組織化学染色はPOLE変異とNSMPサブタイプ子宮体がんの鑑別診断のための潜在的マーカーとなりうるか？","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-07"},"publish_date":"2024-06-07","publish_status":"0","recid":"2000351","relation_version_is_last":true,"title":["ATM immunohistochemistry as a potential marker for the differential diagnosis of no specific molecular profile subtype and POLE-mutation subtype endometrioid carcinoma"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T02:41:41.119517+00:00"}