{"created":"2024-06-07T08:35:03.997709+00:00","id":2000352,"links":{},"metadata":{"_buckets":{"deposit":"73acfae2-2406-4902-a086-861b5595457d"},"_deposit":{"created_by":29,"id":"2000352","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000352"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000352","sets":["57:86"]},"author_link":["144131"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-03-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Exposure to a novel environment is psychologically and physically stressful for humans and animals. The response has been reported to involve enhanced sympathetic nervous system activity, but changes in nutrient levels under stress are not fully understood. As a form of exposure to a novel environment, repeated cage exchange (CE, four times at 2-h intervals for 8 h from 08:00 h) during the light phase with no restraint on movement was applied to A/J mice, a strain particularly prone to stress. Body temperature was measured with a temperature-sensing microchip implanted in the interscapular region. The stress conditions and anxiety level were evaluated by measuring urinary catecholamines and corticosterone and by performing an anxiety-like behavior test, respectively. Major nutrients such as glucose, fatty acids, and amino acids in the plasma were also examined. CE mice showed a significant increase in body temperature with each CE. They also showed a significantly greater reduction of body weight change, more water intake, and higher levels of urinary catecholamines and corticosterone and anxiety-like behavior score than control mice. The model revealed a significantly lower plasma glucose level and higher levels of several essential amino acids, such as branched-chain amino acids and phenylalanine, than those of control mice. Meanwhile, free fatty acids and several amino acids such as arginine, aspartic acid, proline, threonine, and tryptophan in both sets of mice were significantly decreased from the corresponding levels at 08:00 h, while similar plasma levels were exhibited between mice with and without CE. In conclusion, repeated CE stress was associated with changes in glucose and amino acids in plasma. Although further study is needed to clarify how these changes are specifically linked to anxiety-like behavior, this study suggests the potential for nutritional intervention to counter stress in humans exposed to novel environments.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Sayuri Fushuku, Miharu Ushikai, Emi Arimura, Yuga Komaki,Masahisa Horiuchi\nAcute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice\nPLoS ONE 18(10): e0292649\nhttps://doi.org/10.1371/journal.pone.0292649","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第731号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:堀内正久】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-11-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"冨宿, 小百合","creatorNameLang":"ja"},{"creatorName":"Fushuku, Sayuri","creatorNameLang":"en"}],"familyNames":[{"familyName":"冨宿","familyNameLang":"ja"},{"familyName":"Fushuku","familyNameLang":"en"}],"givenNames":[{"givenName":"小百合","givenNameLang":"ja"},{"givenName":"Sayuri","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144131","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Diss_FUSHUKU_Sayuri_ISK731_2023.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_FUSHUKU_Sayuri_ISK731_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000352/files/Diss_FUSHUKU_Sayuri_ISK731_2023.pdf"},"version_id":"8eb2756e-594a-4f1d-b046-b54d4c89dd71"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Abstract_FUSHUKU_Sayuri_4520800138_2023.pdf","filesize":[{"value":"24.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_FUSHUKU_Sayuri_4520800138_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000352/files/Abstract_FUSHUKU_Sayuri_4520800138_2023.pdf"},"version_id":"993fd055-8667-4a35-b41b-dbc0fb931ca7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Result_FUSHUKU_Sayuri_isk_731.pdf","filesize":[{"value":"201 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_FUSHUKU_Sayuri_isk_731","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000352/files/Result_FUSHUKU_Sayuri_isk_731.pdf"},"version_id":"bff1cd7d-cffe-4268-972a-e2343faf0ecd"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Comments_FUSHUKU_Sayuri_isk_731.pdf","filesize":[{"value":"141 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_FUSHUKU_Sayuri_isk_731","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000352/files/Comments_FUSHUKU_Sayuri_isk_731.pdf"},"version_id":"ef153753-9f65-4344-842f-7b02450cab02"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Acute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Acute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice","subitem_title_language":"en"},{"subitem_title":"雄マウスにおいて急性の繰り返しのケージ交換ストレスは、尿中ストレスと血漿代謝プロファイルを変化させる","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-07"},"publish_date":"2024-06-07","publish_status":"0","recid":"2000352","relation_version_is_last":true,"title":["Acute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T02:41:45.858016+00:00"}