{"created":"2024-06-07T08:35:11.022545+00:00","id":2000354,"links":{},"metadata":{"_buckets":{"deposit":"3efac7f8-5385-47b4-ac7b-d9de9af62c7a"},"_deposit":{"created_by":29,"id":"2000354","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000354"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000354","sets":["57:86"]},"author_link":["144133"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-03-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"There are few reports on the long-term clinical outcome after percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) complicated with frailty. This novel study investigated the association between pre-PCI frailty and long-term clinical outcomes in elderly patients aged 65 years or older with stable CAD who underwent elective PCI. We assessed 239 consecutive patients aged 65 years or older with stable CAD who underwent successful elective PCI at Kagoshima City Hospital between January 1st, 2017 and December 31st, 2020. Frailty was retrospectively assessed using the Canadian Study and Aging Clinical Frailty Scale (CFS). Based on the pre-PCI CFS, patients were divided into two groups: the non-frail (CFS < 5) and the frail (CFS ≥ 5) group. We investigated the association between pre-PCI CFS and major adverse cardiovascular events (MACEs) defined as the composite of all-cause death, non-fatal myocardial infarction, non-fatal stroke, and heart failure requiring hospitalization. Additionally, we assessed the association between pre-PCI CFS and major bleeding events defined as Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding. The mean age was 74.8 ± 7.0 years, and 73.6% were men. According to the pre-PCI frailty assessment, 38 (15.9%) and 201 (84.1%) were classified as frail and non-frail groups, respectively. During a median follow-up of 962 (607–1284) days, 46 patients developed MACEs and 10 patients developed major bleeding events. Kaplan–Meier curves showed a significantly higher incidence of MACE in the frail group compared to those in the non-frail group (Log-rank p < 0.001). Even in multivariate analysis, pre-PCI frailty (CFS ≥ 5) was independently associated with MACE (HR 4.27, 95% CI 1.86–9.80, p-value: < 0.001). Additionally, the cumulative incidence of major bleeding events was significantly higher in the frail group than in the non-frail group (Log-rank p = 0.001). Pre-PCI frailty was an independent risk factor for MACE and bleeding events in elderly patients with stable CAD who underwent elective PCI.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Hirokazu Shimono, Akihiro Tokushige, Daisuke Kanda, Ayaka Ohno, Masao Hayashi, Mana Fukuyado, Mitsumasa Akao, Mariko Kawasoe, Ryo Arikawa, Hideaki Otsuji, Hideto Chaen, Hideki Okui, Naoya Oketani & Mitsuru Ohishi\nAssociation of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention\nHeart and Vessels 38, 1205–1217 (2023)\nhttps://doi.org/10.1007/s00380-023-02276-3","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"The version of record of this article, first published in Heart and Vessels, is available online at Publisher’s website: https://doi.org/10.1007/s00380-023-02276-3","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第733号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:大石充】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-11-01"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下野, 洋和","creatorNameLang":"ja"},{"creatorName":"Shimono, Hirokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"下野","familyNameLang":"ja"},{"familyName":"Shimono","familyNameLang":"en"}],"givenNames":[{"givenName":"洋和","givenNameLang":"ja"},{"givenName":"Hirokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144133","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Diss_SHIMONO_Hirokazu_ISK733_2023.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_SHIMONO_Hirokazu_ISK733_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000354/files/Diss_SHIMONO_Hirokazu_ISK733_2023.pdf"},"version_id":"dfe15e51-98e7-41e1-8036-f782abe29f0c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Abstract_SHIMONO_Hirokazu_4520810116_2023.pdf","filesize":[{"value":"81.4 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KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_SHIMONO_Hirokazu_isk_733","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000354/files/Result_SHIMONO_Hirokazu_isk_733.pdf"},"version_id":"a8996e95-7045-491d-b253-07792f56d77b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Comments_SHIMONO_Hirokazu_isk_733.pdf","filesize":[{"value":"134 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_SHIMONO_Hirokazu_isk_733","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000354/files/Comments_SHIMONO_Hirokazu_isk_733.pdf"},"version_id":"b38da614-3167-46f4-a15b-3198f735287f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Clinical frailty scale","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stable coronary artery disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Percutaneous coronary intervention","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Clinical outcome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention","subitem_title_language":"en"},{"subitem_title":"経皮的冠動脈インターベンション後の安定冠動脈疾患を有する高齢者における術前の臨床的虚弱性と臨床転帰の関連性","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-07"},"publish_date":"2024-06-07","publish_status":"0","recid":"2000354","relation_version_is_last":true,"title":["Association of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T02:41:56.056354+00:00"}