{"created":"2024-06-07T08:35:14.598758+00:00","id":2000355,"links":{},"metadata":{"_buckets":{"deposit":"98066b04-08cf-430d-b007-461b097bc3a4"},"_deposit":{"created_by":29,"id":"2000355","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000355"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000355","sets":["57:86"]},"author_link":["144134"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-03-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Background\nWe evaluated the effect of recombinant human hepatocyte growth factor (rh-HGF) on intestinal adaptation in a rat model of short-bowel syndrome (SBS).\nMethods\nSprague–Dawley rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90 % small bowel resection. The animals were divided into 3 groups: TPN/SBS (control group, n = 7), TPN/SBS/intravenous recombinant human hepatocyte growth factor (HGF) (0.3 mg/kg/day) (HGF group, n = 7), and TPN/SBS/intravenous c-Met inhibitor (0.3 mg/kg/day) (anti-HGF group, n = 5). On day 7, rats were euthanized and histologically evaluated. Serum diamine oxidase (S-DAO) levels were evaluated using an enzyme-linked immunosorbent assay. The nutrient transporter and glucagon-like peptide-2 (GLP-2) receptor expression were evaluated using real-time polymerase chain reaction.\nResults\nThe jejunal and ileal villus heights were higher and the S-DAO concentrations significantly higher (p = 0.04) in the HGF group than in the control and anti-HGF groups. The sodium-dependent glucose transporter 1 expression in the HGF group was significantly higher than in the control group and significantly suppressed in the anti-HGF group (p < 0.01). The peptide transporter 1 expression in the jejunum was higher in the HGF group than in the other groups and significantly suppressed in the anti-HGF group (p < 0.01). The GLP-2 receptor expression in the jejunum was higher in the HGF group than the other groups, and it was significantly suppressed in the anti-HGF group (p < 0.01). These jejunal results regarding nutrient transporter an GLP-2 receptor were not found in the ileum.\nConclusions\nThe administration of rh-HGF appears to be more effective in the jejunum than in the ileum.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Koshiro Sugita, Keisuke Yano, Shun Onishi, Yumiko Iwamoto, Masato Ogata, Lynne Takada, Chihiro Kedoin, Murakami Masakazu, Toshio Harumatsu, Takafumi Kawano, Mitsuru Muto, Kotaro Kumagai, Akio Ido, Tatsuru Kaji, Satoshi Ieiri\nSuperiority of Intestinal Adaptation by Hepatocyte Growth Factor in the Jejunum: An Experimental Study in a Short-Bowel Rat Model\nJournal of Pediatric Surgery, Volume 59, Issue 4, 2024, Pages 627-633\nhttps://doi.org/10.1016/j.jpedsurg.2023.11.028","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第734号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:家入里志】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2024-01-10"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉田, 光士郎","creatorNameLang":"ja"},{"creatorName":"Sugita, Koshiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"杉田","familyNameLang":"ja"},{"familyName":"Sugita","familyNameLang":"en"}],"givenNames":[{"givenName":"光士郎","givenNameLang":"ja"},{"givenName":"Koshiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144134","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Diss_SUGITA_Koshiro_ISK734_2023.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Diss_SUGITA_Koshiro_ISK734_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000355/files/Diss_SUGITA_Koshiro_ISK734_2023.pdf"},"version_id":"f25fb886-0e27-4e78-85d7-051c209a1b4b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Abstract_SUGITA_Koshiro_4520810134_2023.pdf","filesize":[{"value":"81.0 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_SUGITA_Koshiro_4520810134_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000355/files/Abstract_SUGITA_Koshiro_4520810134_2023.pdf"},"version_id":"d5717206-7e90-45d6-a28f-f262ece278c9"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Result_SUGITA_Koshiro_isk_734.pdf","filesize":[{"value":"197 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_SUGITA_Koshiro_isk_734","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000355/files/Result_SUGITA_Koshiro_isk_734.pdf"},"version_id":"e58fa792-6675-44e7-90d7-fb783dceb9d8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Comments_SUGITA_Koshiro_isk_734.pdf","filesize":[{"value":"142 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_SUGITA_Koshiro_isk_734","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000355/files/Comments_SUGITA_Koshiro_isk_734.pdf"},"version_id":"3828fca3-eeb6-4fa5-aec2-4a8d6cf6f801"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Short-bowel syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocyte growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat massive small bowel resection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestinal adaptation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Superiority of intestinal adaptation by hepatocyte growth factor in the jejunum: An experimental study in a short-bowel rat model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Superiority of intestinal adaptation by hepatocyte growth factor in the jejunum: An experimental study in a short-bowel rat model","subitem_title_language":"en"},{"subitem_title":"肝細胞増殖因子の空腸に対する腸管順応促進効果の優位性―短腸ラットモデルを用いた研究","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-07"},"publish_date":"2024-06-07","publish_status":"0","recid":"2000355","relation_version_is_last":true,"title":["Superiority of intestinal adaptation by hepatocyte growth factor in the jejunum: An experimental study in a short-bowel rat model"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-11T02:42:00.823796+00:00"}