{"created":"2024-06-07T08:35:21.402316+00:00","id":2000357,"links":{},"metadata":{"_buckets":{"deposit":"ec47a12d-e3ee-4208-a910-7111131cf5b4"},"_deposit":{"created_by":29,"id":"2000357","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000357"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000357","sets":["57:86"]},"author_link":["144136"],"control_number":"2000357","item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2024-03-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Coronin proteins are actin-related proteins containing WD repeat domains encoded by seven genes (CORO1A, CORO1B, CORO1C, CORO2A, CORO2B, CORO6, and CORO7) in the human genome. Analysis of large cohort data from The Cancer Genome Atlas revealed that expression of CORO1A, CORO1B, CORO1C, CORO2A, and CORO7 was significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) tissues (p < 0.05). Moreover, high expression of CORO1C and CORO2A significantly predicted the 5 year survival rate of patients with PDAC (p = 0.0071 and p = 0.0389, respectively). In this study, we focused on CORO1C and investigated its functional significance and epigenetic regulation in PDAC cells. Knockdown assays using siRNAs targeting CORO1C were performed in PDAC cells. Aggressive cancer cell phenotypes, especially cancer cell migration and invasion, were inhibited by CORO1C knockdown. The involvement of microRNAs (miRNAs) is a molecular mechanism underlying the aberrant expression of cancer-related genes in cancer cells. Our in silico analysis revealed that five miRNAs (miR-26a-5p, miR-29c-3p, miR-130b-5p, miR-148a-5p, and miR-217) are putative candidate miRNAs regulating CORO1C expression in PDAC cells. Importantly, all five miRNAs exhibited tumor-suppressive functions and four miRNAs except miR-130b-5p negatively regulated CORO1C expression in PDAC cells. CORO1C and its downstream signaling molecules are potential therapeutic targets in PDAC.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Kosuke Fukuda, Naohiko Seki, Ryutaro Yasudome, Reiko Mitsueda, Shunichi Asai, Mayuko Kato,Tetsuya Idichi, Hiroshi Kurahara and Takao Ohtsuka\nCoronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma\nGenes 2023, 14(5), 995\nhttps://doi.org/10.3390/genes14050995","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第736号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:大塚隆生】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2023-12-06"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 皓佑","creatorNameLang":"ja"},{"creatorName":"Fukuda, Kosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"福田","familyNameLang":"ja"},{"familyName":"Fukuda","familyNameLang":"en"}],"givenNames":[{"givenName":"皓佑","givenNameLang":"ja"},{"givenName":"Kosuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144136","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Diss_FUKUDA_Kosuke_ISK736_2023.pdf","filesize":[{"value":"7.1 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_FUKUDA_Kosuke_ISK736_2023.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000357/files/Diss_FUKUDA_Kosuke_ISK736_2023.pdf"},"version_id":"67b8475c-17ef-411e-b11c-de277e6689bb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-11"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Abstract_FUKUDA_Kosuke_4520810297_2023.pdf","filesize":[{"value":"101.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_FUKUDA_Kosuke_4520810297_2023.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000357/files/Abstract_FUKUDA_Kosuke_4520810297_2023.pdf"},"version_id":"8be0927c-475f-48fb-af64-5e11fdf3bfe2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Result_FUKUDA_Kosuke_isk_736.pdf","filesize":[{"value":"184 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_FUKUDA_Kosuke_isk_736","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000357/files/Result_FUKUDA_Kosuke_isk_736.pdf"},"version_id":"252d7c15-ec59-4f2e-a5f2-ed30023a70a6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2024-03-08"}],"filename":"Comments_FUKUDA_Kosuke_isk_736.pdf","filesize":[{"value":"140 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_FUKUDA_Kosuke_isk_736","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000357/files/Comments_FUKUDA_Kosuke_isk_736.pdf"},"version_id":"be8f691e-39cc-4e85-b040-67b259e9bbf2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pancreatic ductal adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"coronin-family","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CORO1C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-26a-5p","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-29c-3p","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma","subitem_title_language":"en"},{"subitem_title":"複数の癌抑制型マイクロRNAの制御を受けるCoronin1Cは、膵菅腺癌の遊走能、浸潤能を促進する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-07"},"publish_date":"2024-06-07","publish_status":"0","recid":"2000357","relation_version_is_last":true,"title":["Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-09-12T04:17:08.672333+00:00"}