{"created":"2025-05-07T06:47:44.608615+00:00","id":2000850,"links":{},"metadata":{"_buckets":{"deposit":"5fc81b0b-4643-4e78-9e85-0be8482fd679"},"_deposit":{"created_by":29,"id":"2000850","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000850"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000850","sets":["57:86"]},"author_link":["144485"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2025-03-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2025-03-19"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Hepatocyte growth factor (HGF) serves key roles in cell motility, proliferation and immunoregulatory functions. However, the effect of HGF on macrophages is unclear. The present study aimed to elucidate the effect of HGF on the phenotypic alterations of intestinal lamina propria mononuclear cells (LPMCs). Colitis was induced in a mouse model using dextran sodium sulfate (DSS). Subsequently, LPMCs were isolated from the mice with chronic colitis and the expression levels of cytokine‑encoding genes in the LPMCs were determined. CD11b‑positive macrophages isolated from LPMCs were cultured with HGF, and alterations in the levels of M1 or M2 markers were evaluated by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and flow cytometry. In addition, the cytokine levels were assessed using RT‑qPCR and ELISA. HGF shifted the phenotype of macrophages from M1 to M2‑like, as determined by increased mRNA expression levels of arginase‑1, CD206 and IL‑10, and reduced mRNA expression levels of CD86 and IL‑6 in mice with DSS‑induced colitis. Moreover, HGF could ameliorate DSS‑induced colitis owing to its immunosuppressive effect on immune cells. These findings indicated that HGF treatment may not only promote the regeneration of epithelial cells but also lead to tissue repair by phenotypic alteration of M1 macrophages to M2‑like macrophages.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Yusuke Fujino, Shuji Kanmura, Yuko Morinaga, Issei Kojima, Nobuhisa Maeda, Akihito Tanaka, Hidehito Maeda, Kotaro Kumagai, Fumisato Sasaki, Shiroh Tanoue, Akio Ido\nHepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a mouse model by altering the phenotype of intestinal macrophages\nMol Med Rep 27: 70, 2023\nhttps://doi.org/10.3892/mmr.2023.12957","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第770号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:井戸章雄】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2025-02-05"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤野, 悠介","creatorNameLang":"ja"},{"creatorName":"FUJINO, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144485","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-22"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Diss_FUJINO_Yusuke_ISK770_2024.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"Diss_FUJINO_Yusuke_ISK770_2024.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000850/files/Diss_FUJINO_Yusuke_ISK770_2024.pdf"},"version_id":"0d743757-9127-4398-8e1f-d5eeca709f37"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-22"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Abstract_FUJINO_Yusuke_4519800091_2024.pdf","filesize":[{"value":"78.6 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KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comment_FUJINO_Yusuke_isk_770.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000850/files/Comment_FUJINO_Yusuke_isk_770.pdf"},"version_id":"22ac17f2-32ea-41e9-a043-2cb1f58f4b33"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IBD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phenotypic alteration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a mouse model by altering the phenotype of intestinal macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a mouse model by altering the phenotype of intestinal macrophages","subitem_title_language":"en"},{"subitem_title":"肝細胞増殖因子（HGF）は、マウスモデルにおいて腸管マクロファージの表現型を変化させることによってデキストラン硫酸ナトリウム（DSS）誘発性の大腸炎を改善する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-05-07"},"publish_date":"2025-05-07","publish_status":"0","recid":"2000850","relation_version_is_last":true,"title":["Hepatocyte growth factor ameliorates dextran sodium sulfate‑induced colitis in a mouse model by altering the phenotype of intestinal macrophages"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-10-22T06:53:50.347221+00:00"}