{"created":"2025-05-07T06:47:49.452416+00:00","id":2000851,"links":{},"metadata":{"_buckets":{"deposit":"24b36ae2-34a7-465d-b879-9d9178c92a1e"},"_deposit":{"created_by":29,"id":"2000851","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2000851"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02000851","sets":["57:86"]},"author_link":["144486"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2025-03-07","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2025-03-19"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Objective: To establish an animal model of modified cuff tear arthropathy (mCTA) in order to better replicate the pathophysiology associated with rotator cuff tear-induced humeral head collapse.\nDesign: mCTA was induced by transection of the rotator cuff, the long head of the biceps brachii (LHB), and superior half of the joint capsule in the right shoulder of 12-week-old rats; the left shoulder underwent sham surgery. The severity of CTA was quantitated using the Murine Shoulder Arthritis Score (MSAS). The trabecular bone of the humeral head and metaphysis was analyzed using bone histomorphometry. The expression of proinflammatory cytokines and catabolic enzymes was evaluated immunohistochemically.\nResults: In the mCTA model, the MSAS increased starting from 2 weeks after induction, and there was notable subchondral bone collapse with fibrous cells at 4 weeks. The mCTA cartilage exhibited positive staining for TNF-α, IL-1β/6, MMP-3/13, and ADAMTS5. The trabecular bone volume was reduced not only in the subchondral bone but also in the metaphysis of the humeri, and bone resorption was enhanced in these areas. In the collapsed subchondral bone, both bone formation and resorption were increased. The fibrous cells showed expression of TNF-α, IL-6, and MMP-13, along with specific markers of mesenchymal stem cells. Furthermore, the fibrous cells showed osteoblastic characteristics (RUNX2-positive) and expressed RANKL.\nConclusions: The LHB and the capsuloligamentous complex are critical stabilizers of the glenohumeral joint, serving to prevent the advancement of CTA following massive rotator cuff tears. Fibrous cells appear to play a role in the humeral head bone resorption.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"T. Ijuin, T. Iuchi, H. Tawaratsumida, Y. Masuda, A. Tokushige, S. Maeda, N. Taniguchi\nDevelopment of a novel animal model of rotator cuff tear arthropathy replicating clinical features of progressive osteoarthritis with subchondral bone collapse\nOsteoarthritis and Cartilage Open, Volume 5, Issue 3, 2023, 100389\nhttps://doi.org/10.1016/j.ocarto.2023.100389","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第771号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:谷口昇】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2024-10-02"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊集院, 俊郎","creatorNameLang":"ja"},{"creatorName":"IJUIN, Toshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144486","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-22"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Diss_ IJUIN_Toshiro_ISK771_2024.pdf","filesize":[{"value":"5.8 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"Diss_ IJUIN_Toshiro_ISK771_2024.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2000851/files/Diss_ IJUIN_Toshiro_ISK771_2024.pdf"},"version_id":"99890cac-6681-4aeb-8b28-32dfc9007bb7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-22"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Abstract_IJUIN_Toshiro_4519810051_2024.pdf","filesize":[{"value":"82.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_IJUIN_Toshiro_4519810051_2024.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2000851/files/Abstract_IJUIN_Toshiro_4519810051_2024.pdf"},"version_id":"62b51775-8a59-429b-8445-d92d482f9af3"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-05-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Result_IJUIN_Toshiro_isk_771.pdf","filesize":[{"value":"115.7 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_IJUIN_Toshiro_isk_771.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000851/files/Result_IJUIN_Toshiro_isk_771.pdf"},"version_id":"85ad573b-34aa-40a0-b41f-67de8e4e581c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-05-07"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-03-07"}],"filename":"Comment_IJUIN_Toshiro_isk_771.pdf","filesize":[{"value":"59.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comment_IJUIN_Toshiro_isk_771.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2000851/files/Comment_IJUIN_Toshiro_isk_771.pdf"},"version_id":"0d655ecf-7724-4f98-819a-5081d5d085ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cuff tear arthropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Subchondral bone collapse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Long head of biceps","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Capsuloligamentous complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrous cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Development of a novel animal model of rotator cuff tear arthropathy replicating clinical features of progressive osteoarthritis with subchondral bone collapse","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of a novel animal model of rotator cuff tear arthropathy replicating clinical features of progressive osteoarthritis with subchondral bone collapse","subitem_title_language":"en"},{"subitem_title":"腱板断裂性変形関節症の臨床的所見である軟骨下骨圧壊を再現する新規動物モデルの開発","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-05-07"},"publish_date":"2025-05-07","publish_status":"0","recid":"2000851","relation_version_is_last":true,"title":["Development of a novel animal model of rotator cuff tear arthropathy replicating clinical features of progressive osteoarthritis with subchondral bone collapse"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-10-22T06:53:54.949826+00:00"}