{"created":"2025-06-04T01:54:22.054282+00:00","id":2001050,"links":{},"metadata":{"_buckets":{"deposit":"a18e9dec-e382-4c56-920d-b27098fc4f70"},"_deposit":{"created_by":29,"id":"2001050","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"2001050"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:02001050","sets":["57:86"]},"author_link":["144625"],"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2025-05-08","subitem_date_issued_type":"Collected"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"2025-05-22"}]},"item_5_degree_grantor_53":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鹿児島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17701","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_42":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Doctor of Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_5_description_17":{"attribute_name":"ファイル（説明）","attribute_value_mlt":[{"subitem_description":"博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Objective: To evaluate the humeral head bone volume of patients with cuff tear arthropathy (CTA) and examine the therapeutic effect of zoledronate in a rat modified model of CTA (mCTA).\nDesign: The bone mass in patients with CTA was measured using Hounsfield units from CT images. The mCTA was induced by transecting the rotator cuff, biceps brachii tendon, and superior half of the joint capsule in adult rat shoulders. A single subcutaneous injection of zoledronate was followed by bone histomorphometry and immunohistochemistry of the humeral head, as well as the Murine Shoulder Arthritis Score (MSAS) assessment.\nResults: The humeral head bone volume was decreased in patients with CTA. In the mCTA model, M1 macrophages were increased in the synovium and were decreased by zoledronate treatment. The increased expressions of TNF-α, IL-1β and IL-6 in mCTA synovium and articular cartilage were suppressed in the zoledronate-treated mCTA group. The expression of catabolic enzymes in the articular cartilage and MSAS showed similar results. The zoledronate-treated mCTA group showed a decreased subchondral bone collapse with a decreased RANKL/OPG expression ratio and a suppressed number of osteoclasts compared with the control mCTA group. The enhanced expressions of HMGB1 and S100A9 in the mCTA shoulders were eliminated in the zoledronate-treated mCTA group.\nConclusions: The humeral head subchondral bone was decreased in patients with CTA. In the mCTA model, the collapse and osteoarthritic changes were prevented by zoledronate administration. Zoledronate seemed to suppress the number of M1 macrophages in the synovium and osteoclasts in the subchondral bone.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Hiroki Tawaratsumida, Tomohiro Iuchi, Yusuke Masuda, Takayuki Ide, Shingo Maesako, Takasuke Miyazaki, Toshiro Ijuin, Shingo Maeda, Noboru Taniguchi\nZoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy\nOsteoarthritis and Cartilage 33 (2025) 101–115\nhttps://doi.org/10.1016/j.joca.2024.08.005","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_dissertation_number_55":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲総研第790号"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【指導教員:谷口昇】"}]},"item_5_text_47":{"attribute_name":"date.appl","attribute_value_mlt":[{"subitem_text_value":"【学位申請日】2024-12-11"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"俵積田, 裕紀","creatorNameLang":"ja"},{"creatorName":"TAWARATSUMIDA, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"144625","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-27"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-05-08"}],"filename":"Diss_TAWARATSUMIDA_Hiroki_ISK790_2025.pdf","filesize":[{"value":"13.4 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"Diss_TAWARATSUMIDA_Hiroki_ISK790_2025.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2001050/files/Diss_TAWARATSUMIDA_Hiroki_ISK790_2025.pdf"},"version_id":"3e020868-6d65-4478-95fe-1fac34b6063c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-10-27"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-05-08"}],"filename":"Abstract_TAWARATSUMIDA_Hiroki_4519810230_2025.pdf","filesize":[{"value":"78.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Abstract_TAWARATSUMIDA_Hiroki_4519810230_2025.pdf","objectType":"abstract","url":"https://ir.kagoshima-u.ac.jp/record/2001050/files/Abstract_TAWARATSUMIDA_Hiroki_4519810230_2025.pdf"},"version_id":"6e2883f2-09f1-4a83-a9ee-95f163bb63d9"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-04"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-05-08"}],"filename":"Result_TAWARATSUMIDA_Hiroki_isk_790.pdf","filesize":[{"value":"112.6 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Result_TAWARATSUMIDA_Hiroki_isk_790.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2001050/files/Result_TAWARATSUMIDA_Hiroki_isk_790.pdf"},"version_id":"9f5044de-d1b8-4d09-b2b8-4178f88a2c61"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-06-04"}],"displaytype":"detail","fileDate":[{"fileDateType":"Collected","fileDateValue":"2025-05-08"}],"filename":"Comments_TAWARATSUMIDA_Hiroki_isk_790.pdf","filesize":[{"value":"79.4 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"Comments_TAWARATSUMIDA_Hiroki_isk_790.pdf","objectType":"other","url":"https://ir.kagoshima-u.ac.jp/record/2001050/files/Comments_TAWARATSUMIDA_Hiroki_isk_790.pdf"},"version_id":"89ca8968-4739-4635-b943-596abb0c1c86"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cuff tear arthropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Zoledronate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Subchondral bone collapse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy","subitem_title_language":"en"},{"subitem_title":"ゾレドロン酸はラット腱板断裂性肩関節症モデルの軟骨下骨の陥没と関節軟骨変性を抑制する","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"29","path":["86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-06-04"},"publish_date":"2025-06-04","publish_status":"0","recid":"2001050","relation_version_is_last":true,"title":["Zoledronate alleviates subchondral bone collapse and articular cartilage degeneration in a rat model of rotator cuff tear arthropathy"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2025-10-27T07:16:46.535126+00:00"}