@article{oai:ir.kagoshima-u.ac.jp:00000214,
 author = {Kitano, Motoo and Lehner, Charles E. and Taya, Yasushi and Ozaki, Hiroshi S. and Takenaka, Masami and Kawashima, Mahito},
 issue = {1},
 journal = {南太平洋研究, South Pacific Study},
 month = {},
 note = {Previously we proposed a hypothesis that activation of blood coagulability in the intraosseous blood vessels contr ibutes impor tantly to produce decompression sickness (DCS) including dysbaric osteonecrosis (DON) after a hyperbar ic exposure. This paper presents evidence suppor ting this hypothesis. Crossbred, adult, female sheep were exposed to a three-hour exposure at 2.8-3.2 atm abs, using an experimental hyperbar ic chamber . They showed signs of bends in various legs soon after the exposure.
Eight weeks after decompression insult, more or less marked and extensive pathologic findings of the bone mar row tissue wer e noted at the time of autopsy in their tibiae. In three tibiae of seven exper imental ・・sheep, a wide spread necrosis was found in the bone mar row, particular ly in the upper half of the shaft. ・・
In one of them, the large branches including the main ascending branch of the intraosseous nutrient artery were obliterated by organized thrombi at a little above the middle portion of the shaft of the right tibia. This arterial lesion seemed closely related to a widespread necrosis of the bone mar row of upper half of the shaft. Another conspicuous finding was formation of cutting cones, a repair process, observed in the cortical compact bone. Through formation of cutting cones, blood supply of the cortical bone recovered from the periosteum resulting in an active organization of necrotic bone mar row, where active formation of woven bone was observed. These suggest that provocative hyperbaric exposure can cause
arterial thrombosis to produce early stage of necrosis of the bone tissues, and the subsequent repair processes can exaggerate the features of DON.},
 pages = {17--31},
 title = {Histopathological Study on Dysbaric Osteonecrosis (DON) in Tibiae of Sheep with a Hyperbaric Exposure},
 volume = {18},
 year = {1997}
}