@techreport{oai:ir.kagoshima-u.ac.jp:00002200,
 author = {松田, 史代 and MATSUDA, Fumiyo},
 month = {2016-10-27},
 note = {2009-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：21700539　研究代表者：松田史代 (鹿児島大学医学部助教), 本研究では、リハビリテーションの視点から、リハビリテーション介入が脳血管障害後の脳の可塑性を促せるのか、脳血管障害後の神経栄養因子MKの働きについて検討するとともに、神経栄養因子が神経細胞死や神経修復にどのように働いているのか検討することを目的とする。経時的に脳梗塞モデルを作成し、術1日後よりトレッドミル運動介入を行い、トレッドミル介入群と非介入群における脳梗塞体積測定後、パラフィン切片作成し、免疫組織化学染色にて観察した。その結果、免疫組織化学染色結果より、家兎MK 免疫組織化学染色にて、トレッドミル介入群が非介入群に比べて3日後で有意に発現面積が増加していた。また、神経学的機能では
運動群が非運動群よりも回復が早く、運動機能（棒上歩行機能評価）でも運動群で非運動群と比較し、良好な運動機能回復がみられた。, The purpose of this study was to investigate the effects of early treadmill training after cerebral infarction in rats. This study might provide a basic evidence of rehabilitation medicine. Fifty-four- 8-week old male Wistar rats weighing 200-300g were used in this study. The filament (4-0 nylon suture with blunted tip) was inserted into the left common carotid artery by an arteriotomy. It was then passed up through the lumen of the internal carotid artery and lodged in the narrow proximal anterior cerebral artery, blocking the MCA at its origin. Reperfusion was established by withdrawal of the filament by 90 min. Next day after surgery, stroke rats were randomly assigned to two groups: treadmill-exercised group or non-exercised controls. After ischemia, the rats were received to run on a treadmill for 20 min once a day. All rats were observed the absence of motor coordination and neurological deficits after surgery. The improvement of the motor behavioral and the neurological score in the exercised groups was better than those in non-exercised groups. Particularly, the score in the exercised groups was significantly improved compared with those in non-exercised groups at 14 days after surgery (P<0.05). The runner had the increased expression of midkine (MK) over the non-runner with or without MCA occlusion for 3 days.},
 title = {脳血管障害後の早期運動療法介入が脳の可塑性に与える影響について},
 year = {},
 yomi = {マツダ, フミヨ}
}