{"created":"2023-07-25T08:04:06.847690+00:00","id":2223,"links":{},"metadata":{"_buckets":{"deposit":"420aa922-c035-4778-a698-73e3c4a6945b"},"_deposit":{"created_by":3,"id":"2223","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2223"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002223","sets":[]},"author_link":["11743","117838","117837"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Novel function of histamine in atherosclerotic artery"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ドウミャク コウカ ケッカン ニオケル アタラシイ ヒスタミン ノ キノウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-04-01"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20590416　研究代表者：谷本昭英 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"血管壁でのヒスタミンと動脈硬化の関連について、apoE-KOマウスとヒスタミン受容体欠損マウス (H1Rおよび H2R) あるいはヒスタミン合成酵素 (HDC) 欠損マウスを交配した２重欠損マウスを作成した (apoE-H1R-DKO, apoE-H2R-DKO およびapoE-HDC-DKO マウス)。高コレステロール食 (12週間：1.25%コレステロール、15%ラード、0.5%コール酸) 投与により粥腫形成を誘導し、各マウスについて、病理形態学的評価、動脈硬化関連の炎症因子等の遺伝子発現をRT-PCRなどで検討した。高コレステロ－ル食により、apoE-H2R-DKOおよびapoE-HDC-KOマウスでは、apoE-KOマウスより重篤な高脂血症を呈するにも関わらず、粥腫形成はむしろ抑制されており、動脈硬化病変の炎症を惹起する炎症性サイトカインやスカベンジャー受容体の発現は減少していた。apoE-KOマウスを背景にした粥腫モデルにおいて、ヒスタミン２型受容体によるシグナルは血管壁での炎症制御を介して病変形成に重要な働きをしている。","subitem_description_type":"Other"},{"subitem_description":"The relation of histamine signaling in the arterial wall and atherogenesis was investigated using apoE-H1R-KO, apoE-H2R-KO and apoE-HDC-KO mice. The mice were fed by high cholesterol diet (1.25% cholesterol, 15% lard and 0.5% cholic acid) for 12 weeks, and pathological examination and expression of inflammation-related genes were evaluated in the aortas. Even the high cholesterol diet induced much higher hypercholesterolemia in apoE-H2R-KO and apoE-HDC-KO mice, the atherosclerotic lesion formation and expression of many inflammation-related genes were reduced in these KO mice than in apoE-KO mice. The histamine signaling mediated through H2 receptor would play a pivotal role in atherogenesis by regulating the inflammatory response in the vascular wall.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"タニモト, アキヒデ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"TANIMOTO, Akihide"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20590416"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"谷本, 昭英"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"20590416seika.pdf","filesize":[{"value":"454.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20590416seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/2223/files/20590416seika.pdf"},"version_id":"be0a1b3f-30c1-4bf0-8a4b-b13751358834"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒスタミン","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒスタミンレセプター(HR)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒスチジン脱炭酸酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"HDC/apoE-KOマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"HR/apoE-KOマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"スカベンジャー受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"動脈硬化血管における新しいヒスタミンの機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"動脈硬化血管における新しいヒスタミンの機能"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"2223","relation_version_is_last":true,"title":["動脈硬化血管における新しいヒスタミンの機能"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:48.279774+00:00"}