{"created":"2023-07-25T08:04:06.889526+00:00","id":2224,"links":{},"metadata":{"_buckets":{"deposit":"69d972d0-141c-4233-8a96-d47ed2723f63"},"_deposit":{"created_by":3,"id":"2224","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2224"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002224","sets":[]},"author_link":["117840","11746","117839"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Developing new treatment modalities of bladder cancer on the basis of microRNA expression profile"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"microRNA ハツゲン プロファイル ニ モトズク ボウコウガン ノ シンキ チリョウ ノ カイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20591861　研究代表者：川元健 (鹿児島大学大学院医歯学総合研究科研究員)","subitem_description_type":"Other"},{"subitem_description":"157種microRNAスクリーニングによる臨床膀胱癌のmicroRNA発現プロファイルを作成した。膀胱癌で有意に発現が抑制されていたmicroRNA（miR-133a, miR-145など）を癌抑制的microRNAの候補とし、それらの標的遺伝子(KRT-7, FSCN1, GST-P1)は癌遺伝子的作用を有することが機能解析実験で明らかになった。またmiR-96, miR-183の臨床膀胱癌検体における発現は正常組織と比べ有意に上昇しており、腫瘍マーカーとしての有用性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"We screened 157 microRNAs and identified the microRNA profile in clinical bladder cancer. We focused on the down-regulated microRNAs, such as miR-133a, and miR-145, which may have tumor suppressive function. Transfection of the target genes, such as KRT-7, FSCN1, and GST-P1, revealed that these genes might have oncogenic function. On the other hand, the expression levels of the up-regulated microRNAs, such as miR-96, miR-183, were indeed over-expressed in bladder cancer, suggesting that they might be potential biomarkers for bladder cancer.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"カワモト, ケン"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KAWAMOTO, Ken"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20591861"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川元, 健"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"20591861seika.pdf","filesize":[{"value":"414.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20591861seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/2224/files/20591861seika.pdf"},"version_id":"beebeeb4-7bce-4caa-9148-fc1764059c2f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"microRNA発現プロファイルに基づく膀胱癌の新規治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"microRNA発現プロファイルに基づく膀胱癌の新規治療の開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"2224","relation_version_is_last":true,"title":["microRNA発現プロファイルに基づく膀胱癌の新規治療の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:48.495838+00:00"}