@misc{oai:ir.kagoshima-u.ac.jp:00002354,
 author = {古謝, 将一郎 and Kosha, Shoichiro},
 month = {},
 note = {Hypoestrogenism due lo castration induces bone mineral loss in premenopausal women. However，it remains unclear as to whether or not there is an age-related difference in bone mineralloss due to castration. To investigate the aging effect on bone mineralloss due to castration，several studies were performed. 1) The effect of surgical castration on femoral bone mineral density (BMD) in female Sprague-Dawley rats at various ages was examined. 2) The effect of surgical castration on lumbar spine BMD (L2-L4) in premenopausal women was investigated. 3) The effect of medical castration with a gonadotropin-releasing hormone agonist on lumbar spine BMD in premenopausal women was also assessed. 1) The percent changes in femoral BMD 12 weeks after castration were +4.4% compared to baseline levels in rats that were castrated at 8 weeks of age，-0.8% at 16 weeks，-7.7% at 24 weeks，and -11.2% at 32 weeks. Rats that were castrated at higher ages showed greater bone mineral loss than younger aged-ovariectomized-rats. 2) The percent changes in lumbar spine BMD 6 months after surgical castration in women in their forties were -3.98 ± 2.04% compared to baseline levels，which was significantly greater than those in women in their thirties (-1.34 ± 2.48%)( P < 0.05).　3 )　The percent change in the lumbar spine BMD 6 months after medical castration in women in their forties was -4.15% compared to baseline levels， which was significantly greater than that in women in their thirties (-0.05%) (P < 0.05). Based on these results, we conclude that there is an age-related difference in bone mineral loss due to castration. Higher aged-premenopausal women undergo greater bone mineral loss than younger-aged women. This may be attributable to age-related differences in bone metabolism even in premenopausal women., 医歯学総合研究科博士論文(医学) ; 学位取得日: 平成11年7月16日},
 title = {加齢が去勢後骨塩量に及ぼす影響に関する研究},
 year = {1999},
 yomi = {コシャ, ショウイチロウ}
}