{"created":"2023-07-25T08:04:12.556662+00:00","id":2354,"links":{},"metadata":{"_buckets":{"deposit":"9332c76d-bc8f-478e-bd1a-2eddda1a584f"},"_deposit":{"created_by":3,"id":"2354","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2354"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002354","sets":["228:230:5139","57:86"]},"author_link":["124482"],"control_number":"2354","item_5_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"87","bibliographicPageStart":"79","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_5_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"1999-07-16","subitem_date_issued_type":"Issued"}]},"item_5_date_granted_54":{"attribute_name":"学位授与年月日 ","attribute_value_mlt":[{"subitem_dategranted":"1999-07-16"}]},"item_5_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Hypoestrogenism due lo castration induces bone mineral loss in premenopausal women. However，it remains unclear as to whether or not there is an age-related difference in bone mineralloss due to castration. To investigate the aging effect on bone mineralloss due to castration，several studies were performed. 1) The effect of surgical castration on femoral bone mineral density (BMD) in female Sprague-Dawley rats at various ages was examined. 2) The effect of surgical castration on lumbar spine BMD (L2-L4) in premenopausal women was investigated. 3) The effect of medical castration with a gonadotropin-releasing hormone agonist on lumbar spine BMD in premenopausal women was also assessed. 1) The percent changes in femoral BMD 12 weeks after castration were +4.4% compared to baseline levels in rats that were castrated at 8 weeks of age，-0.8% at 16 weeks，-7.7% at 24 weeks，and -11.2% at 32 weeks. Rats that were castrated at higher ages showed greater bone mineral loss than younger aged-ovariectomized-rats. 2) The percent changes in lumbar spine BMD 6 months after surgical castration in women in their forties were -3.98 ± 2.04% compared to baseline levels，which was significantly greater than those in women in their thirties (-1.34 ± 2.48%)( P < 0.05).　3 )　The percent change in the lumbar spine BMD 6 months after medical castration in women in their forties was -4.15% compared to baseline levels， which was significantly greater than that in women in their thirties (-0.05%) (P < 0.05). Based on these results, we conclude that there is an age-related difference in bone mineral loss due to castration. Higher aged-premenopausal women undergo greater bone mineral loss than younger-aged women. This may be attributable to age-related differences in bone metabolism even in premenopausal women.","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"医歯学総合研究科博士論文(医学) ; 学位取得日: 平成11年7月16日","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3157102","subitem_identifier_reg_type":"JaLC"}]},"item_5_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"カゴシマ ダイガク","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_5_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://id.ndl.go.jp/bib/000000342292","subitem_relation_type_select":"URI"}}]},"item_5_relation_33":{"attribute_name":"関連（isVersionOf）","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dl.ndl.go.jp/info:ndljp/pid/3157102","subitem_relation_type_select":"URI"}}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0368-5063","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_5_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"495","subitem_subject_scheme":"NDC"}]},"item_5_text_44":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"平成22年度に行われた国立国会図書館の学位論文（博士）デジタル化事業に際し、著者から、学位授与大学において、国立国会図書館から譲渡を受けた学位論文のデジタル化複製物を利用（全文複写提供、公衆送信）に供することの許諾を受けたものです（参考：http://www.ndl.go.jp/jp/aboutus/digitization_theses.html）。"}]},"item_5_text_52":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"医論第1247号"}]},"item_5_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古謝, 将一郎","creatorNameLang":"ja"},{"creatorName":"コシャ, ショウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kosha, Shoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"000000342292.pdf","filesize":[{"value":"7.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000342292.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2354/files/000000342292.pdf"},"version_id":"852dc046-8bb4-448d-80f2-18ed287a728f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Age","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bone mineral density","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Castration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Premenopausal women","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"加齢が去勢後骨塩量に及ぼす影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"加齢が去勢後骨塩量に及ぼす影響に関する研究","subitem_title_language":"ja"},{"subitem_title":"Age-Related Difference in Bone Mineral Loss due to Surgical or Medical Castration","subitem_title_language":"en"},{"subitem_title":"カレイ ガ キョセイゴ コツエンリョウ ニ オヨボス エイキョウ ニ カンスル ケンキュウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"5","owner":"3","path":["5139","86"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-17"},"publish_date":"2015-03-17","publish_status":"0","recid":"2354","relation_version_is_last":true,"title":["加齢が去勢後骨塩量に及ぼす影響に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-01-09T04:57:00.026806+00:00"}