@article{oai:ir.kagoshima-u.ac.jp:00002454,
 author = {ORDONEZ, Paula},
 issue = {2},
 journal = {鹿児島大学医学雑誌, Medical journal of Kagoshima University},
 month = {},
 note = {Epstein-Barr virus (EBV)-encoded BARF1 is suspected to play an important role in development of EBV-associated gastric carcinoma (EBV-GC). The present study examined the sequence variation of BARF1-promoter region (‒488/+87) of EBV genomes detected in 22 Colombian and 17 Japanese EBV-GCs. In addition, the EBV genomes in throat washing samples from 11 Colombian and 9 Japanese healthy donors (controls) were examined. All the EBV strains isolated from healthy donors had the same BARF1-promoter-region sequence as the prototype strain B95-8. In contrast, the EBV-GCs showed the following 8 point mutations in comparison with the B95-8 strain: G→C at ‒367 in 2 Colombian EBV-GC cases; T→A at ‒356 in 1 Colombian EBV-GC case; C→G at +15 in 1 Colombian EBV-GC case; C→T at +24 in 5 Colombian EBVGC cases; T→G at +26 in 3 Colombian EBV-GC cases; T→C at +29 in 7 and 2 Colombian and Japanese EBV-GC cases, respectively; T→A at +44 in 5 Colombian EBV-GC cases; and G→A at +46 in 1 Japanese EBV-GC case. The observed casecontrol difference at position +29 was statistically significant (p=0.022, Fisher’s exact test). Although the frequency of this point mutation in Colombian EBV-GCs was higher than that in Japanese EBV-GCs, the difference was not statistically significant (p=0.251). In summary, the present study, examining the BARF1-promoter region of EBV genomes detected in 39 EBV-GCs and throat washing specimens from 20 healthy donors, found a statistically significant increase of the point mutation of T→C at position +29 in EBV-GC. Further studies seem warranted to clarify the etiological significance of this finding.},
 pages = {19--27},
 title = {Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma},
 volume = {61},
 year = {2009}
}