{"created":"2023-07-25T08:04:17.010527+00:00","id":2454,"links":{},"metadata":{"_buckets":{"deposit":"3e714e15-250e-441a-8698-b6988e089fb1"},"_deposit":{"created_by":3,"id":"2454","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2454"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002454","sets":["228:230:5161","57:58:59"]},"author_link":["119084","119085"],"item_7_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Epstein-Barrウイルス（EBV）関連胃がんにおけるEBV-BARF1遺伝子配列の変異"}]},"item_7_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"27","bibliographicPageStart":"19","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"鹿児島大学医学雑誌"},{"bibliographic_title":"Medical journal of Kagoshima University","bibliographic_titleLang":"en"}]}]},"item_7_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-09-01"}]},"item_7_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Epstein-Barr virus (EBV)-encoded BARF1 is suspected to play an important role in development of EBV-associated gastric carcinoma (EBV-GC). The present study examined the sequence variation of BARF1-promoter region (‒488/+87) of EBV genomes detected in 22 Colombian and 17 Japanese EBV-GCs. In addition, the EBV genomes in throat washing samples from 11 Colombian and 9 Japanese healthy donors (controls) were examined. All the EBV strains isolated from healthy donors had the same BARF1-promoter-region sequence as the prototype strain B95-8. In contrast, the EBV-GCs showed the following 8 point mutations in comparison with the B95-8 strain: G→C at ‒367 in 2 Colombian EBV-GC cases; T→A at ‒356 in 1 Colombian EBV-GC case; C→G at +15 in 1 Colombian EBV-GC case; C→T at +24 in 5 Colombian EBVGC cases; T→G at +26 in 3 Colombian EBV-GC cases; T→C at +29 in 7 and 2 Colombian and Japanese EBV-GC cases, respectively; T→A at +44 in 5 Colombian EBV-GC cases; and G→A at +46 in 1 Japanese EBV-GC case. The observed casecontrol difference at position +29 was statistically significant (p=0.022, Fisher’s exact test). Although the frequency of this point mutation in Colombian EBV-GCs was higher than that in Japanese EBV-GCs, the difference was not statistically significant (p=0.251). In summary, the present study, examining the BARF1-promoter region of EBV genomes detected in 39 EBV-GCs and throat washing specimens from 20 healthy donors, found a statistically significant increase of the point mutation of T→C at position +29 in EBV-GC. Further studies seem warranted to clarify the etiological significance of this finding.","subitem_description_type":"Other"}]},"item_7_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"オルドネス, パウラ"}]}]},"item_7_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0368-5063","subitem_source_identifier_type":"ISSN"}]},"item_7_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00040104","subitem_source_identifier_type":"NCID"}]},"item_7_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"498","subitem_subject_scheme":"NDC"}]},"item_7_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_7_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_7_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ORDONEZ, Paula"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"AN00040104_v61n2_p19-27.pdf","filesize":[{"value":"253.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00040104_v61n2_p19-27.pdf","url":"https://ir.kagoshima-u.ac.jp/record/2454/files/AN00040104_v61n2_p19-27.pdf"},"version_id":"188144e2-d7fa-49fd-9b34-2ed7801005a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Epstein-Barr virus","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"BARF1 promoter","subitem_subject_scheme":"Other"},{"subitem_subject":"viral oncogene","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma"}]},"item_type_id":"7","owner":"3","path":["59","5161"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-07-03"},"publish_date":"2012-07-03","publish_status":"0","recid":"2454","relation_version_is_last":true,"title":["Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T11:21:49.481064+00:00"}