{"created":"2023-07-25T08:04:19.044114+00:00","id":2490,"links":{},"metadata":{"_buckets":{"deposit":"a0566730-5508-4c6c-bac9-9c62c5cc9f5e"},"_deposit":{"created_by":18,"id":"2490","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2490"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002490","sets":["57:80"]},"author_link":["13155"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(B)))研究成果報告書　課題番号：21390525　研究代表者：野口和行 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"本研究は、iPS細胞による歯周組織再生の可能性の検討とヒト歯肉線維芽細胞由来iPS細胞の樹立を目的とした。まず、骨分化刺激したマウスiPS細胞をラットの歯周組織欠損モデルへ移植した。骨分化刺激したiPS細胞は石灰化物の沈着が認められ、この細胞を移植したところ欠損部周囲への新生骨と、象牙質上に新生セメント質様組織が形成された。我々は、ヒト歯肉線維芽細胞由来iPS細胞の樹立にも成功し、新規歯周組織再生療法の基盤を築くことができた。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"The purpose of this study was to investigate the possibility of the periodontal regeneration by iPS cell transplantation and to establish human gingival fibroblast derived iPS cell. Culturing iPS cells in osteogenic medium, we observed calcium diposition by Alizarin Red S staining and osteocalcin positive immunostaining cells. In rat periodontal fenestration model, transplantation of the iPS cells encouraged not only new bone formation but also cementum formation on the denuded dentin surface. Mouse iPS cells stimulated with osteogenic medium promote periodontal regeneration in rat periodontal fenestration model. Moreover, we established human gingival fibroblast derived iPS cell. The results of this study may underlie new periodontal therapy.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21390525"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野口, 和行","creatorNameLang":"ja"},{"creatorName":"NOGUCHI, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13155","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090218298","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"21390525seika.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"21390525seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2490/files/21390525seika.pdf"},"version_id":"5e046617-868d-4301-a5cb-72ba1c9d120b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"iPS細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"歯周組織再生","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"移植・再生医療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"再生・組織","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"iPS細胞を用いた歯周組織再生療法に関する総合的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"iPS細胞を用いた歯周組織再生療法に関する総合的研究","subitem_title_language":"ja"},{"subitem_title":"A comprehensive study on periodontal regeneration using induced pluripotent stem (iPS) cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"2490","relation_version_is_last":true,"title":["iPS細胞を用いた歯周組織再生療法に関する総合的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:23:52.706952+00:00"}