{"created":"2023-07-25T08:04:19.583372+00:00","id":2499,"links":{},"metadata":{"_buckets":{"deposit":"79fd6dee-c812-422c-b24c-67af3e7d0fc8"},"_deposit":{"created_by":3,"id":"2499","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2499"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002499","sets":[]},"author_link":["117848","117847","13189"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Identification of adaptor molecules involved in intracellular transport of cadherins"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"カドヘリン ノ サイボウナイ ユソウ ニ カンヨ スル アダプター ブンシグン ノ ドウテイ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-28"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2009-2011年度科学研究費助成事業(科学研究費補助金(基盤研究(C)))研究成果報告書　課題番号：21590313　研究代表者：小澤政之 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"E-カドヘリンは細胞間の接着分子で、上皮細胞では粗面小胞体で合成された後、細胞表面の側面膜領域に輸送されて、アドへレンスジャンクションと呼ばれる接着装置を形成する。カドヘリンはβ-カテニンを介してα-カテニンと複合体を作るのであるが、β-カテニンと結合しないとE-カドヘリンは細胞表面に輸送されなくなる。ところが、E-カドヘリンをα-カテニンとのキメラ分子にしてやると、輸送されるようになることがわかった。このことは、カドヘリンの輸送においてα-カテニンが重要である事を示している。","subitem_description_type":"Other"},{"subitem_description":"E-cadherin is a member of the cadherin family cell-cell adhesion molecules. After synthesis in rough endoplasmic reticulum, E-cadherin is transported to the baso-lateral membrane of epithelial cells, and forms cell adhesion complex called adherens junction. Cadherins forms complexes with α-catenin through the interaction withβ-catenin. Uncoupling ofβ-catenin-binding results in failure of cadherin transport to the cell surface. Chimeric molecules of E-cadherin with α-catenin, however, are transported to the surface. Thus complex formation of cadherins withα -catenin is critical for the transport.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"オザワ, マサユキ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"OZAWA, Masayuki"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"21590313"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小澤, 政之"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"21590313seika.pdf","filesize":[{"value":"267.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"21590313seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/2499/files/21590313seika.pdf"},"version_id":"82d39938-b04e-4196-9100-1c033b123c45"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カドヘリン","subitem_subject_scheme":"Other"},{"subitem_subject":"β-カテニン","subitem_subject_scheme":"Other"},{"subitem_subject":"α-カテニン","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内輸送","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"カドヘリンの細胞内輸送に関与するアダプター分子群の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カドヘリンの細胞内輸送に関与するアダプター分子群の同定"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-24"},"publish_date":"2014-12-24","publish_status":"0","recid":"2499","relation_version_is_last":true,"title":["カドヘリンの細胞内輸送に関与するアダプター分子群の同定"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:51.877205+00:00"}