{"created":"2023-07-25T08:04:20.066751+00:00","id":2510,"links":{},"metadata":{"_buckets":{"deposit":"972eebfc-ec56-4846-87c2-a84eb5c78947"},"_deposit":{"created_by":3,"id":"2510","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2510"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002510","sets":[]},"author_link":["117855","13246","117856"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Induced pluripotent stem (iPS) cells in co-culture with periodontal ligament cells"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"iPS サイボウ ノ シシュウ ソシキ カンサイボウ エノ ブンカ ユウドウ キコウ ノ カイメイ : カンサイボウ ニッチ カラノ アプローチ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2012-05-31"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2010-2011年度科学研究費助成事業(科学研究費補助金(若手研究(B)))研究成果報告書　課題番号：22792093　研究代表者：迫田賢二 (鹿児島大学大学院医歯学総合研究科助教)","subitem_description_type":"Other"},{"subitem_description":"本研究はiPS細胞を歯周組織幹細胞へ導くために、歯周組織幹細胞ニッチとして考えられる歯周組織由来細胞とiPS細胞を共培養することを試みた。まず、骨分化刺激したマウスiPS細胞をラットの歯周組織欠損モデルへ移植したところ、新生骨と、新生セメント質様組織が形成された。次に、歯根膜由来細胞とiPS細胞を共培養した。遺伝子発現を網羅的に解析したところ、骨形成関連遺伝子の発現が上昇すると同時に、そのシグナルが抑制されるような遺伝子発現の変化を認めた。","subitem_description_type":"Other"},{"subitem_description":"The purpose of this study was to induce the periodontal ligament stem cells from iPS\ncell by co-culture with periodontal ligament cells. In rat periodontal fenestration model, transplantation of the iPS cells encouraged not only new bone formation but also cementum formation on the denuded dentin surface. In the co-culture system, undifferentiated iPS cells were decreased. We investigated the gene expression using PrimerArray®. The differentiated iPS cells increased BMP-2, TGF-β2, and Noggin mRNA expression levels compared with control, while Smad9 and BMPR-1b mRNA expression level were decreased. Further studies are necessary.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"サコダ, ケンジ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"SAKODA, Kenji"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"22792093"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"迫田, 賢二"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"22792093seika.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22792093seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/2510/files/22792093seika.pdf"},"version_id":"e603f1d8-a60e-4089-a1e2-3fe0470ce4e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"iPS細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"再生・組織","subitem_subject_scheme":"Other"},{"subitem_subject":"組織幹細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"iPS細胞の歯周組織幹細胞への分化誘導機構の解明 : 幹細胞ニッチからのアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"iPS細胞の歯周組織幹細胞への分化誘導機構の解明 : 幹細胞ニッチからのアプローチ"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-22"},"publish_date":"2014-12-22","publish_status":"0","recid":"2510","relation_version_is_last":true,"title":["iPS細胞の歯周組織幹細胞への分化誘導機構の解明 : 幹細胞ニッチからのアプローチ"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:52.813797+00:00"}