{"created":"2023-07-25T08:04:35.503599+00:00","id":2807,"links":{},"metadata":{"_buckets":{"deposit":"bcf0a373-b0ad-4d84-a29f-2d74c51eddc4"},"_deposit":{"created_by":18,"id":"2807","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"2807"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00002807","sets":["57:78"]},"author_link":["116827","116828","116829","116830","116831","116832","116833"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"822","bibliographicPageStart":"817","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"International Journal of Oncology","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-04-01","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"The constitutive activation of the Notch pathway has been demonstrated in various types of malignancies. However, it remains unclear how the Notch pathway is involved in the pathogenesis of oral squamous cell carcinoma (OSCC). We investigated the expression of Notch pathway molecules in OSCC cell lines and biopsy specimens and examined the effect of Notch pathway inhibition. Reverse transcription-polymerase chain reaction revealed upregulation of Notch1, Notch2, Jagged1, HES1 and HEY1 in both OSCC cell lines and biopsy specimens. Immunohistochemical examination showed that the Notch intracellular domain accumulates in the nucleus of cells in OSCC cell lines and biopsy specimens. In addition, Jagged1 is expressed in the cytoplasm of cells in OSCC cell lines and biopsy specimens. Furthermore, Notch pathway inhibition using a Á-secretase inhibitor prevented the growth of OSCC in vitro. These findings suggest that inhibition of the Notch pathway suppresses OSCC growth and may be a useful approach for thetreatment of patients with OSCC.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/ijo_00000558","subitem_relation_type_select":"DOI"}}]},"item_6_relation_32":{"attribute_name":"関連（relation）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.spandidos-publications.com/ijo/36/4/817","subitem_relation_type_select":"URI"}}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10196439","subitem_source_identifier_type":"PISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"496.8","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hijioka, Hiroshi","creatorNameLang":"en"},{"creatorName":"ヒジオカ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"比地岡, 浩志","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Setoguchi, Takao","creatorNameLang":"en"},{"creatorName":"セトグチ, タカオ","creatorNameLang":"ja-Kana"},{"creatorName":"瀬戸口, 啓夫","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyawaki, Akihiko","creatorNameLang":"en"},{"creatorName":"ミヤワキ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"宮脇, 昭彦","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gao, Hui","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishida, Takayuki","creatorNameLang":"en"},{"creatorName":"イシダ, タカユキ","creatorNameLang":"ja-Kana"},{"creatorName":"石田, 喬之","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komiya, Setsuro","creatorNameLang":"en"},{"creatorName":"コミヤ, セツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"小宮, 節郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Norifumi","creatorNameLang":"en"},{"creatorName":"ナカムラ, ノリフミ","creatorNameLang":"ja-Kana"},{"creatorName":"中村, 典史","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"Upregulation of Notch pathway molecules in oral squamous cell carcinoma.pdf","filesize":[{"value":"595.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Upregulation of Notch pathway molecules in oral squamous cell carcinoma.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/2807/files/Upregulation of Notch pathway molecules in oral squamous cell carcinoma.pdf"},"version_id":"be75f22a-6030-4bd8-9b1d-1e233bbc62ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"oral squamous cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Notch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"γ-secretase inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Upregulation of Notch pathway molecules in oral squamous cell carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Upregulation of Notch pathway molecules in oral squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-02-10"},"publish_date":"2014-02-10","publish_status":"0","recid":"2807","relation_version_is_last":true,"title":["Upregulation of Notch pathway molecules in oral squamous cell carcinoma"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:18:57.056828+00:00"}