{"created":"2023-07-25T08:04:47.047359+00:00","id":3042,"links":{},"metadata":{"_buckets":{"deposit":"9ac987ba-da3a-4f91-93d4-da190c3a8b80"},"_deposit":{"created_by":3,"id":"3042","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3042"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00003042","sets":[]},"author_link":["117870","15439","117869"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of microRNA in diabetes associated vascular dysfunction"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"micro RNA ニヨル トウニョウビョウセイ ケッカン ビョウヘン ケイセイ ノ メカニズム ノ カイメイ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-13"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2013-2013年度科学研究費助成事業（研究活動スタート支援）研究成果報告書　課題番号：25893192　研究代表者：山口宗一（鹿児島大学・医歯（薬）学総合研究科・准教授）","subitem_description_type":"Other"},{"subitem_description":"「糖尿病性の血管病変形成に血小板と血管内皮細胞のクロストークが必要である」という仮説の第一段階を検証した。マイクロRNA(microRNA)は蛋白合成を制御して細胞の機能を制御する。今回の新しい知見は、血管内皮細胞においてmiR-503が低酸素刺激で誘導され、cyclinDの発現のみならずAktの活性化を制御していることと、血管内皮細胞はmiR-503を放出と取り込みをすることである。血管内皮細胞のmiR-503がどのようにPI3K-Aktシグナルの下流を制御しているか、miR-503を介した血小板と血管内皮細胞の細胞間情報伝達がどのように行われるか、などが、今後の検討課題である。","subitem_description_type":"Other"},{"subitem_description":"Diabetes is one of the major public health problem. Dysfunction of endothelial  cells are involved in formation of the pathogenesis of this vascular diseases associated with diabetes. Our hypothesis is that cell to cell communication between endothelial cells and platelets would play a pivotal role in diabetic vascular complications. microRNAs (miRNAs) is a non-coding miRNAs that regulates protein synthesis post-transcriptionally. We used miRNAs as key players to organize a series of vascular events un der hyperglycemia. We have discovered that miR-503 was induced by hypoxia in cultured endothelial cells and that miR-503 regulates phosphorylation of Akt as well as cyclin D. We also observed that miR-503 is released by wrapping in exosomes under hypoxic condition. In the future studies, we will focus on the downstream target of Akt regulated by miR-503 in endothelial cells and clarify the mechanisms by which endothelial cells transfer the information to platelets.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ヤマグチ, ムネカズ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"YAMAGUCHI, Munekazu"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"25893192"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山口, 宗一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"25893192_山口宗一.pdf","filesize":[{"value":"355.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25893192_山口宗一.pdf","url":"https://ir.kagoshima-u.ac.jp/record/3042/files/25893192_山口宗一.pdf"},"version_id":"42135422-c39c-4b02-ab46-64dc19c6d1d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"血小板","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"エクソゾーム","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"microRNAによる糖尿病性血管病変形成のメカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"microRNAによる糖尿病性血管病変形成のメカニズムの解明"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-14"},"publish_date":"2015-05-14","publish_status":"0","recid":"3042","relation_version_is_last":true,"title":["microRNAによる糖尿病性血管病変形成のメカニズムの解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:49.296469+00:00"}