{"created":"2023-07-25T08:04:47.642679+00:00","id":3051,"links":{},"metadata":{"_buckets":{"deposit":"cf57ff18-aa3a-400e-8c39-46b663089721"},"_deposit":{"created_by":3,"id":"3051","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3051"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00003051","sets":[]},"author_link":["106319","106318","15461"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Involvement of MARCKS on methylmercury neurotoxicity and application as a marker for neurotoxicity"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"シンケイ ドクセイ ハツゲン キジョ ニオケル MARCKS ノ シンケイ ドクセイ マーカー エノ オウヨウ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-16"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（若手研究（B））研究成果報告書　課題番号：23780298　研究代表者：白石光也（鹿児島大学・獣医学部・准教授）","subitem_description_type":"Other"},{"subitem_description":"MARCKSは神経細胞の発達と成熟に必須のタンパク質であることから、未だ不明な点が多いメチル水銀毒性発現機序におけるMARCKSの関与を検討した。メチル水銀はSH-SY5Y細胞において細胞生存率の低下を引き起こすと同時に、MARCKS発現量とリン酸化量を変化させることを示し、このリン酸化異常のメカニズムを明らかにした。さらに、メチル水銀中毒モデルラットの脳におけるMARCKSリン酸化の異常を示し、メチル水銀毒性の発現機序にMARCKSが関与していることを示した。","subitem_description_type":"Other"},{"subitem_description":"Because myristoylated  alanine-rich C kinase substrate (MARCKS) plays an essential role in the differentiation and development of neuronal cells, we studied the alteration of MARCKS expression and phosphorylation in MeHg-induced neurotoxicity of neuroblastoma SH-SY5Y cells and in the rat brain. Exposure to MeHg induced a decrease in cell viability of SH-SY5Y cells, which was accompanied by an alteration of MARCKS phosphorylation and expression. In brain tissue from MeHg-treated rats, abnormal MARCKS phosphorylation was observed. The present study may indicate that alteration in MARCKS has consequences for MeHg-induced neurotoxicity.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"シライシ, ミツヤ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"SHIRAISHI, Mitsuya"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23780298"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白石, 光也"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23780298_白石光也.pdf","filesize":[{"value":"885.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"23780298_白石光也.pdf","url":"https://ir.kagoshima-u.ac.jp/record/3051/files/23780298_白石光也.pdf"},"version_id":"19330702-5437-47ca-bbd1-61e9b09ba16b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メチル水銀","subitem_subject_scheme":"Other"},{"subitem_subject":"MARCKS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"神経毒性発現機序におけるMARCKSの関与と神経毒性マーカーへの応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経毒性発現機序におけるMARCKSの関与と神経毒性マーカーへの応用"}]},"item_type_id":"8","owner":"3","path":["135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-20"},"publish_date":"2015-05-20","publish_status":"0","recid":"3051","relation_version_is_last":true,"title":["神経毒性発現機序におけるMARCKSの関与と神経毒性マーカーへの応用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-09-01T10:12:50.517189+00:00"}