{"created":"2023-07-25T08:04:48.094635+00:00","id":3060,"links":{},"metadata":{"_buckets":{"deposit":"9caa613a-937e-404e-9b0e-27db297bccfb"},"_deposit":{"created_by":18,"id":"3060","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"3060"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00003060","sets":["57:80"]},"author_link":["15486"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-11","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書　課題番号：23592739　研究代表者：坂東健二郎（鹿児島大学・医歯（薬）学総合研究科・助教）","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"LPSにより誘導される高OPN骨芽細胞は正常に骨分化する能力を有していた。また、高OPN骨芽細胞はメカニカルストレスの感受性が低かった。これにはLmw-ptpの発現が高くなることが関係していると考えられる。また、OPN-Lmw-ptp系はメカにストレスを負荷した際のFAKのリン酸化を抑制的に調節していることが関係していると考えられる。しかし、OPN、Lmw-ptp、FAKがどのように相互作用しているのかはまだ不明のままである。今後、研究が進めば、高OPN骨芽細胞は炎症性骨疾患の治療のターゲットとなる可能性がある。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"LPS-induced hyper OPN osteoblasts have an ability of osteoblastic differentiation and respond to mechanical stress less than low OPN cells. Lmw-ptp is up-regulated in hyper OPN osteoblast and decreases phosphorylation of FAK induced by mechanical stress. Though, it is unclear how OPN interacts with Lmw-ptp and FAK. Hyper OPN osteoblasts may be an intriguing target to dvelop therapeutic drugs against inflammatory bone diseases.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"23592739"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂東, 健二郎","creatorNameLang":"ja"},{"creatorName":"BANDOW, Kenjiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"23592739_坂東健二郎.pdf","filesize":[{"value":"115.0 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"23592739_坂東健二郎.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/3060/files/23592739_坂東健二郎.pdf"},"version_id":"759854aa-6e49-47a0-b61f-2182ff380180"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"OPN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LPS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lmw-ptp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FAK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"elaidic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"LPSで誘導される高OPN骨芽細胞の骨免疫学的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"LPSで誘導される高OPN骨芽細胞の骨免疫学的解析","subitem_title_language":"ja"},{"subitem_title":"Characterization of LPS-induced hyper OPN osteoblasts","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["80"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"3060","relation_version_is_last":true,"title":["LPSで誘導される高OPN骨芽細胞の骨免疫学的解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-05-24T00:23:56.695678+00:00"}