@article{oai:ir.kagoshima-u.ac.jp:00003124,
 author = {Matsubara, Syhuichiro and 松原, 修一郎 and Ding, Qiang and 丁, 強 and Miyazaki, Yumi and 宮崎, 優美 and Kuwahata, Taisaku and 桑畑, 太作 and Tsukasa, Koichiro and 政, 幸一郎 and Takao, Sonshin and 高尾, 尊身},
 journal = {Scientific Reports},
 month = {},
 note = {Pancreatic cancer is characterized by near-universal mutations in KRAS. The mammalian target of rapamycin (mTOR), which functions downstream of RAS, has divergent effects on stem cells. In the present study, we investigated the significance of the mTOR pathway in maintaining the properties of pancreatic cancer stem cells. The mTOR inhibitor, rapamycin, reduced the viability of CD133+ pancreatic cancer cells and sphere formation which is an index of self-renewal of stem-like cells, indicating that the mTOR pathway functions to maintain cancer stem-like cells. Further, rapamycin had different effects on CD133+ cells compared to cyclopamine which is an inhibitor of the Hedgehog pathway. Thus, the mTOR pathway has a distinct role although both pathways maintain pancreatic cancer stem cells. Therefore, mTOR might be a promising target to eliminate pancreatic cancer stem cells.},
 pages = {1--10},
 title = {mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions},
 volume = {3},
 year = {2013},
 yomi = {マツバラ, シュウイチロウ and ミヤザキ, ユミ and クワハタ, タイサク and ツカサ, コウイチロウ and タカオ, ソンシン}
}