{"created":"2023-07-25T08:04:50.853946+00:00","id":3124,"links":{},"metadata":{"_buckets":{"deposit":"d5b96641-23f7-4ecb-935e-9b11f0ce7b36"},"_deposit":{"created_by":18,"id":"3124","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"3124"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00003124","sets":["57:78"]},"author_link":["116862","116863","116864","116865","116866","116867"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013-11-15","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Pancreatic cancer is characterized by near-universal mutations in KRAS. The mammalian target of rapamycin (mTOR), which functions downstream of RAS, has divergent effects on stem cells. In the present study, we investigated the significance of the mTOR pathway in maintaining the properties of pancreatic cancer stem cells. The mTOR inhibitor, rapamycin, reduced the viability of CD133+ pancreatic cancer cells and sphere formation which is an index of self-renewal of stem-like cells, indicating that the mTOR pathway functions to maintain cancer stem-like cells. Further, rapamycin had different effects on CD133+ cells compared to cyclopamine which is an inhibitor of the Hedgehog pathway. Thus, the mTOR pathway has a distinct role although both pathways maintain pancreatic cancer stem cells. Therefore, mTOR might be a promising target to eliminate pancreatic cancer stem cells.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group","subitem_publisher_language":"en"}]},"item_6_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep03230","subitem_relation_type_select":"DOI"}}]},"item_6_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"http://www.nature.com/articles/srep03230","subitem_rights_language":"en"}]},"item_6_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"EISSN"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsubara, Syhuichiro","creatorNameLang":"en"},{"creatorName":"マツバラ, シュウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"松原, 修一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ding, Qiang","creatorNameLang":"en"},{"creatorName":"丁, 強","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyazaki, Yumi","creatorNameLang":"en"},{"creatorName":"ミヤザキ, ユミ","creatorNameLang":"ja-Kana"},{"creatorName":"宮崎, 優美","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwahata, Taisaku","creatorNameLang":"en"},{"creatorName":"クワハタ, タイサク","creatorNameLang":"ja-Kana"},{"creatorName":"桑畑, 太作","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukasa, Koichiro","creatorNameLang":"en"},{"creatorName":"ツカサ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"政, 幸一郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takao, Sonshin","creatorNameLang":"en"},{"creatorName":"タカオ, ソンシン","creatorNameLang":"ja-Kana"},{"creatorName":"高尾, 尊身","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"srep03230.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"srep03230.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/3124/files/srep03230.pdf"},"version_id":"7811f05a-de35-4ef1-932d-fafef23102f5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-11-05"},"publish_date":"2015-11-05","publish_status":"0","recid":"3124","relation_version_is_last":true,"title":["mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:19:01.782298+00:00"}