{"created":"2023-07-25T08:05:46.438478+00:00","id":4330,"links":{},"metadata":{"_buckets":{"deposit":"17a40569-a660-4f15-90fb-8166a336ac63"},"_deposit":{"created_by":18,"id":"4330","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"4330"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00004330","sets":["57:78"]},"author_link":["116896","116897","116898","116899","116900","116901","116902","116903","116904"],"item_6_biblio_info_5":{"attribute_name":"収録雑誌名","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"12","bibliographicPageStart":"9","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Dendritic cells","bibliographic_titleLang":"en"}]}]},"item_6_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2001-01-01","subitem_date_issued_type":"Issued"}]},"item_6_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"Synovial cells (SCs) in pathological conditions of synovial tissue were analyzed by means of paraffin-immunohistochemistry in points of immunological phenotypes，which are usually expressed in monocytes/macrophages and dendritic cells. Paraffin sections of 4 cases of non-inflammatory and non-neoplastic synovial tissue, each 1 case of non-specific chronic　synovitis　and　of granulomatous synovitis, 5 cases of rheumatoid arthritis (RA), and 1 case of benign giant cell tumor (GCT) were used. SCs in non-inflammatory and non-neoplastic synovial tissue revealed weak or strong immunoreactivity with CD68 and LN-3 (Ia-like antigen) but did not with thymidine phosphorylase (TP).　SCs in RA expressed strong immunoreactivity with TP. GCT tumor cells showed strong immunoreactivity with CD68, LN-3 and TP. T- and B-cell lymphoproliferative lesions were noted in RA，whereas T-cell-dominated one was seen in the other conditions.　Germinal centers (GCs) in RA associated some CD3-positive T-cells.  Consequently, it was recognized that SCs are of monocytes/macrophage lineage.  In pathological conditions SCs expressed TP especially in RA.　The expression of TP in SCs in RA suggested non-neoplastic genetic alteration in the expression of TP in the pathological conditions.  The unusual expression of TP may induce unusual lymphoproliferative lesion in RA. But the expression of TP in GCT might be as a tumor growth inhibitory factor.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"日本樹状細胞研究会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japanese Dendritic Cells Society","subitem_publisher_language":"en"}]},"item_6_source_id_9":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11039557","subitem_source_identifier_type":"NCID"}]},"item_6_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_6_subject_20":{"attribute_name":"NIIsubject","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_6_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasui, Kazuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakae, Kiyohiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Shin-Ichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuyama, Shin-Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayata, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumo, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yonezawa, Suguru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murata, Fusayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Eiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"DC2001(Hasui).pdf","filesize":[{"value":"4.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DC2001(Hasui).pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/4330/files/DC2001(Hasui).pdf"},"version_id":"3393674d-945a-467d-accc-13c88c937559"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Synovial cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thymidine phosphorylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"giant cell tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synovial cells express thymidine phosphorylase in inflammatory and neoplastic synovial tissue","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synovial cells express thymidine phosphorylase in inflammatory and neoplastic synovial tissue","subitem_title_language":"en"}]},"item_type_id":"6","owner":"18","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-05"},"publish_date":"2014-03-05","publish_status":"0","recid":"4330","relation_version_is_last":true,"title":["Synovial cells express thymidine phosphorylase in inflammatory and neoplastic synovial tissue"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-02-07T06:19:11.017026+00:00"}