@article{oai:ir.kagoshima-u.ac.jp:00004455,
 author = {横山, 聡 and Yokoyama, Satoru and 竹野, 明香 and Takeno, Sayaka and 永田, 敏郎 and Nagata, Toshiro and 清水, 邦義 and Shimizu, Kuniyoshi and 近藤, 隆一郎 and Kondo, Ryuichiro},
 journal = {鹿児島大学農学部演習林研究報告, Research bulletin of the Kagoshima University forests},
 month = {Mar},
 note = {Aqueous, methanol, ethanol or dichloromethane extracts of 22 medicinal plants were examined for their inhibitory activity on 3-hydroxy-3-methylglutaryl coenzyme A  (HMG-CoA) reductase. The samples which showed more than 80 % inhibition at the concentration of 1,000  pg/ml were selected as the potential  HMG-CoA reductase inhibitory ingredients. The aqueous extract of herbal part of Artemisia princeps and the ethanol extract of fruit/seeds of Trachycarpus wagnerianus were selected and showed  HMG-CoA reductase inhibitory activity with 88.1  ± 3.2 % and 83.7  ± 0.3 % at 1,000  pg/ml, respectively., 生薬として用いられている薬用植物22種類を水,メタノール,エタノール,ジクロロメタンで抽出し,各抽出物の3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)レダクターゼ阻害活性を測定した。抽出物濃度1,111_/mlで80%以上の阻害活性を有する試料を選抜した結果,Artemisia princepsとTrachycarpus wagnerianusがHMG-CoAレダクターゼ阻害成分を含む試料として見出された。Artemisia princepsの全草の水抽出物とTrachycarpus wagnerianusの果実と種子の混合物のエタノール抽出物は,抽出物濃度1,111_/mlの試験でそれぞれ88.1±3.2%と83.7±0.3%のHMG-CoAレダクターゼ阻害活性を示した。},
 pages = {37--41},
 title = {Screening of extracts of Japanese medicinal plants for HMG-CoA reductase inhibition},
 volume = {37},
 year = {2010}
}