{"created":"2023-07-25T08:05:59.607864+00:00","id":4613,"links":{},"metadata":{"_buckets":{"deposit":"efe9a5b1-19d1-4fe3-82b6-b4d89a99cb15"},"_deposit":{"created_by":18,"id":"4613","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"4613"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00004613","sets":["82:83"]},"author_link":["22524"],"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-31","subitem_date_issued_type":"Collected"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2007-2010年度科学研究費補助金(若手研究(B))研究成果報告書 課題番号：19791404　研究代表者：達山祥子 (鹿児島大学医学部・歯学部附属病院助教)","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"今回われわれはヒト歯髄細胞およびマウスの象牙芽細胞において、温度感受性イオンチャネルTRPM8が発現していることを遺伝子レベル、タンパクレベルで確認した。また、象牙質歯髄複合体モデルとしてラットの切歯の薄切切片を用いて、象牙芽細胞にTRPM8が発現していることを明らかにした。このことから象牙芽細胞が感覚受容体として機能し近接する末梢神経に痛覚を伝えることにより、象牙質知覚過敏症に関わっている可能性を示すことが出来た。","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"In this study, we confirmed the expression of the transient receptor potential melastatin-8 (TRPM8) in human dental pulp cells and in mouse odontoblasts. Using rat dental pulp slice culture as a dentin-pulp complex models we further revealed TRPM8 expression in rat odontoblasts. Our results indicated that odontoblasts could directly respond to noxious stimuli, example as cold condition, and transduce the signal to the nearby nerves, accordingly odontblasts may be involved in dentin hypersensitivity.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学","subitem_publisher_language":"ja"},{"subitem_publisher":"Kagoshima University","subitem_publisher_language":"en"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"497","subitem_subject_scheme":"NDC"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"19791404"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"達山, 祥子","creatorNameLang":"ja"},{"creatorName":"TATSUYAMA, Shoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22524","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070347095","nameIdentifierScheme":"NRID","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"19791404seika.pdf","filesize":[{"value":"257.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"19791404seika.pdf","objectType":"fulltext","url":"https://ir.kagoshima-u.ac.jp/record/4613/files/19791404seika.pdf"},"version_id":"2e5720e0-7dea-450c-8f3f-9b4b00db18c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"象牙芽歯髄複合体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"温度感受性受容体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"象牙質歯髄複合体培養系を用いた温度痛覚受容体の発現とそのメカニズム解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"象牙質歯髄複合体培養系を用いた温度痛覚受容体の発現とそのメカニズム解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of thermo-sensitive nociceptor expression and mechanism by using dentin-pulp complex culture system","subitem_title_language":"en"}]},"item_type_id":"8","owner":"18","path":["83"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"4613","relation_version_is_last":true,"title":["象牙質歯髄複合体培養系を用いた温度痛覚受容体の発現とそのメカニズム解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-06-10T05:23:18.262370+00:00"}