{"created":"2023-07-25T08:06:01.104437+00:00","id":4647,"links":{},"metadata":{"_buckets":{"deposit":"47c0d79c-d84f-4fc3-baa7-0aaf4ac7dc28"},"_deposit":{"created_by":3,"id":"4647","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4647"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00004647","sets":[]},"author_link":["117895","117896","22676"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"New evaluation for severity of Kawasaki disease using HMGB1 values"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"エンショウ ト サイボウ ショウガイ ノ アクジュンカン ニ カンヨ スル カクナイ タンパク・HMGB1 ニヨル アタラシイ カワサキビョウ ジュウショウド ヒョウカ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-04-12"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20591281　研究代表者：野村裕一 (鹿児島大学大学院医歯学総合研究科准教授)","subitem_description_type":"Other"},{"subitem_description":"High Mobility Group Box 1 (HMGB1)値を用いて川崎病(KD)の重症度評価として免疫グロブリン大量療法 (IVIG)不応例スクリーニングの検討を行った。【方法】KD患児のIVIG前の血清を用いてHMGB1値を初回IVIGで軽快した143例 (反応例)と追加治療を必要とした23例（不応例）を比較検討した。【結果】不応例のHMGB1値は有意に高値だった。ROC解析から得られたHMGB1値のカットオフ値(16 ng/ml)以上を予測不応例とすると、鋭敏度43%、精度73%だった。Gunmaスコア5点以上あるいはHMGB1高値を予測不応例とすると鋭敏度74%、精度63%と感度向上が得られた。【結論】川崎病の重症度評価としてのIVIG治療不応例スクリーニングにはGunmaスコアとHMGB1高値による評価が有用である。","subitem_description_type":"Other"},{"subitem_description":"We examined the efficacy of high mobility group box 1 (HMGB1) value for evaluating the severity of KD. Methods: Serum HMGB1 values were compared between the responders (143 patients) to initial intravenous immunoglobulin (IVIG) and nonresponders (23 patients). Results: Compared with responders, non-responders showed significantly elevated HMGB1 values. ROC analysis revealed an optimal cut-off value for HMGB1 for nonresponders. The sensitivity with high HMGB1 was 43% and accuracy 73%. When predicted non-responder is defined as a patient with Gunma score of 5 or over or high HMGB1 value, the sensitivity was 74% and accuracy 63%. Conclusion: Combinational use of HMGB1 value and Gunma score is useful for determine the severity of KD as the prediction for nonresponder of IVIG.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"ノムラ, ユウイチ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"NOMURA, Yuichi"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"492","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20591281"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野村, 裕一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"20591281seika.pdf","filesize":[{"value":"278.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20591281seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/4647/files/20591281seika.pdf"},"version_id":"f5aae3e5-5217-4b22-8dda-ca6e532a0f29"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"川崎病","subitem_subject_scheme":"Other"},{"subitem_subject":"重症度","subitem_subject_scheme":"Other"},{"subitem_subject":"冠動脈後遺症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫グロブリン治療","subitem_subject_scheme":"Other"},{"subitem_subject":"不応例","subitem_subject_scheme":"Other"},{"subitem_subject":"Gunmaスコア","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症と細胞傷害の悪循環に関与する核内蛋白・HMGB1による新しい川崎病重症度評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症と細胞傷害の悪循環に関与する核内蛋白・HMGB1による新しい川崎病重症度評価"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"4647","relation_version_is_last":true,"title":["炎症と細胞傷害の悪循環に関与する核内蛋白・HMGB1による新しい川崎病重症度評価"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:41.905839+00:00"}