{"created":"2023-07-25T08:06:01.147670+00:00","id":4648,"links":{},"metadata":{"_buckets":{"deposit":"8c8f0d6f-125a-4b2a-b670-b11f0393b8ff"},"_deposit":{"created_by":3,"id":"4648","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4648"},"status":"published"},"_oai":{"id":"oai:ir.kagoshima-u.ac.jp:00004648","sets":[]},"author_link":["117897","117898","22679"],"item_8_alternative_title_18":{"attribute_name":"別言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Functional analysis of polycomb proteins and target molecules in rheumatoid arthritis pathogenesis"}]},"item_8_alternative_title_19":{"attribute_name":"タイトルよみ","attribute_value_mlt":[{"subitem_alternative_title":"ポリコーム タンパク ノ キノウ ト ターゲット イデンシ カイメイ ニヨル カンセツ リウマチ ブンシ ヒョウテキ チリョウホウカイハツ"}]},"item_8_date_6":{"attribute_name":"作成日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-04-08"}]},"item_8_description_4":{"attribute_name":"要約(Abstract)","attribute_value_mlt":[{"subitem_description":"2008-2010年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号：20591786　研究代表者：小宮節郎 (鹿児島大学大学院医歯学総合研究科教授)","subitem_description_type":"Other"},{"subitem_description":"関節リウマチ滑膜細胞、骨肉腫細胞株・骨肉腫患者生検組織でEZH2、BMI-1の発現上昇を認めた。またHistone H3 trimethyl化の上昇を認めた。予想に反してBMI-1とEZH2\nをノックダウンしてもin vitro, in vivoにおいて骨肉腫の増大に変化は認められなかったが、EZH2、BMI-1などのポリコーム蛋白質は関節リウマチや骨肉腫の鑑別、腫瘍マーカーとして有用である可能性が示唆された。","subitem_description_type":"Other"},{"subitem_description":"Expression of EZH2 in synovial cells of rheumatoid arthritis and osteosarcoma cells was increased. BMI-1 was also up-regulated in synovial cells of rheumatoid arthritis and osteosarcoma cells. Expression of EZH2 and BMI-1 was up-regulated in osteosarcoma patient’ biopsy specimens. Immunohistochemical examinations showed　that EZH2 and BMI-1 were up-regulated in osteosarcoma cells and that trimethylation　of histone H3K27 was increased.　Unexpectedly, knock down of EZH2 and BMI-1　prevented osteosarcoma growth neither in vitro nor in vivo. Our findings suggest that EZH2 and BMI-1 may be a antigen of rheumatoid arthritis or osteosarcoma, but are not useful molecular targets of treatment.","subitem_description_type":"Other"}]},"item_8_full_name_2":{"attribute_name":"著者よみ","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"コミヤ, セツロウ"}]}]},"item_8_full_name_3":{"attribute_name":"別言語の著者","attribute_value_mlt":[{"nameIdentifiers":[{}],"names":[{"name":"KOMIYA, Setsuro"}]}]},"item_8_publisher_23":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"鹿児島大学"}]},"item_8_subject_15":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"494","subitem_subject_scheme":"NDC"}]},"item_8_text_24":{"attribute_name":"公開者よみ","attribute_value_mlt":[{"subitem_text_value":"カゴシマ ダイガク"}]},"item_8_text_25":{"attribute_name":"公開者別名","attribute_value_mlt":[{"subitem_text_value":"Kagoshima University"}]},"item_8_text_41":{"attribute_name":"科研費番号 ","attribute_value_mlt":[{"subitem_text_value":"20591786"}]},"item_8_version_type_14":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小宮, 節郎"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-27"}],"displaytype":"detail","filename":"20591786seika.pdf","filesize":[{"value":"186.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20591786seika.pdf","url":"https://ir.kagoshima-u.ac.jp/record/4648/files/20591786seika.pdf"},"version_id":"01507e95-11d9-4e1c-8490-c82aa78b85ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ポリコーム蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"EZH2","subitem_subject_scheme":"Other"},{"subitem_subject":"BMI-1","subitem_subject_scheme":"Other"},{"subitem_subject":"関節リウマチ","subitem_subject_scheme":"Other"},{"subitem_subject":"骨肉腫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ポリコーム蛋白の機能とターゲット遺伝子解明による関節リウマチ分子標的治療法開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ポリコーム蛋白の機能とターゲット遺伝子解明による関節リウマチ分子標的治療法開発"}]},"item_type_id":"8","owner":"3","path":["80"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-06"},"publish_date":"2015-01-06","publish_status":"0","recid":"4648","relation_version_is_last":true,"title":["ポリコーム蛋白の機能とターゲット遺伝子解明による関節リウマチ分子標的治療法開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-12-25T07:18:42.107068+00:00"}